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10.1111/irv.12523

http://scihub22266oqcxt.onion/10.1111/irv.12523
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suck abstract from ncbi


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pmid29144593      Influenza+Other+Respir+Viruses 2019 ; 13 (4): 398-406
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  • Risk factors for seasonal influenza virus detection in stools of patients consulting in general practice for acute respiratory infections in France, 2014-2016 #MMPMID29144593
  • Minodier L; Masse S; Capai L; Blanchon T; Ceccaldi PE; van der Werf S; Hanslik T; Charrel R; Falchi A
  • Influenza Other Respir Viruses 2019[Jul]; 13 (4): 398-406 PMID29144593show ga
  • BACKGROUND: Previous studies reported detection of influenza RNA in stools of patients with seasonal influenza infection. While this detection may have a clinical significance, other factors may influence the stool positivity for influenza viruses. OBJECTIVES: The objective of this study was to investigate demographical, clinical, and microbiological factors which could favor the presence of influenza viral RNA in the stools of patients with laboratory-confirmed influenza infection. METHODS: Acute respiratory infection (ARI) patients were enrolled by general practitioners (GP) during two winter seasons (2014-2016). Nasopharyngeal swabs, stool specimens, and clinical data were collected. Samples were tested for 12 respiratory pathogen groups (nasopharyngeal and stool specimens) and for 12 enteric pathogens (stool specimens). RESULTS: Among the 331 patients with ARI enrolled by GP, 114 (34.4%) presented influenza infection. Influenza RNA was detected in stool samples of 21% (24/114) of the 114 stool specimens analyzed. Hospitalization (adjusted odds ratio (aOR) = 7.8 (95% confidence interval (CI)) [1.7-33.7], P = .02), age between 45 and 64 years (aOR = 4.8 [1.7-14.5], P = .01), consumption of raw shellfish and/or mollusks (aOR = 16.7 [3.6-90.9], P = .00), and use of antibiotics (aOR = 6.4 [2.1-19.8], P = .006) or antiviral treatment (aOR = 7.4 [1.9-29], P = .01) were significantly associated with an increased odds of the detection of influenza RNA in stools. Among the 24 stool samples subjected to viral isolation, no one showed virus growth. CONCLUSIONS: These findings will be useful to studies investigating the dissemination route of influenza viruses to gastrointestinal tract.
  • |*General Practice[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Feces/*virology[MESH]
  • |Female[MESH]
  • |France/epidemiology[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Influenza, Human/*epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx/virology[MESH]
  • |Orthomyxoviridae/genetics/*isolation & purification[MESH]
  • |Prospective Studies[MESH]
  • |RNA, Viral/analysis[MESH]
  • |Respiratory Tract Infections/*epidemiology/virology[MESH]
  • |Risk Factors[MESH]


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