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  • A case of type 2 diabetes mellitus with metformin-associated lactic acidosis initially presenting the appearance of a sulfonylurea-related hypoglycemic attack #MMPMID29123848
  • Nishihama K; Maki K; Okano Y; Hashimoto R; Hotta Y; Uemura M; Yasuma T; Suzuki T; Hayashi T; Ishikawa E; Yano Y; Gabazza EC; Ito M; Takei Y
  • Acute Med Surg 2017[Jan]; 4 (1): 123-126 PMID29123848garesp_yesshow ga
  • Case: A 64-year-old Japanese woman with diabetes mellitus was admitted for hypoglycemia. Her diabetes had been under good control with glimepiride, voglibose, exenatide, and metformin for a few years. Although overt proteinuria was observed, the serum creatinine values were within normal range during the routine outpatient follow-up. Hypoglycemic attack caused by glimepiride and loss of appetite by urinary tract infection were diagnosed. Then, metformin-associated lactic acidosis with acute renal failure caused by dehydration was detected. Outcome: Her condition was improved by continuous veno-venous hemodiafiltration and hemodialysis, known to be useful to remove metformin. Conclusion: We reported a case of metformin-associated lactic acidosis with hypoglycemia during routine treatment of diabetes that was successfully rescued by early renal replacement therapy.
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    123 1.4 2017