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10.1093/infdis/jix571 http://scihub22266oqcxt.onion/10.1093/infdis/jix571 29112724!7335675!29112724     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Infect+Dis 2018 ; 217 (2): 245-256 Nephropedia Template TP {{tp|p=29112724|t=2018. Severe Influenza Is Characterized by Prolonged Immune Activation: Results From the SHIVERS Cohort Study |pdf=|usr=}}{{29112724}} gab.com Text Severe Influenza Is Characterized by Prolonged Immune Activation: Results From the SHIVERS Cohort Study JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=29112724 #FOAvip BACKGROUND: The immunologic factors underlying severe influenza are poorly understood. To address this, we compared the immune responses of influenza-confirmed hospitalized individuals with severe acute respiratory illness (SARI) to those of nonhospitalized individuals with influenza-like illness (ILI). METHODS: Peripheral blood lymphocytes were collected from 27 patients with ILI and 27 with SARI, at time of enrollment and then 2 weeks later. Innate and adaptive cellular immune responses were assessed by flow cytometry, and serum cytokine levels were assessed by a bead-based assay. RESULTS: During the acute phase, SARI was associated with significantly reduced numbers of circulating myeloid dendritic cells, CD192+ monocytes, and influenza virus-specific CD8+ and CD4+ T cells as compared to ILI. By the convalescent phase, however, most SARI cases displayed continued immune activation characterized by increased numbers of CD16+ monocytes and proliferating, and influenza virus-specific, CD8+ T cells as compared to ILI cases. SARI was also associated with reduced amounts of cytokines that regulate T-cell responses (ie, interleukin 4, interleukin 13, interleukin 12, interleukin 10, and tumor necrosis factor beta) and hematopoiesis (interleukin 3 and granulocyte-macrophage colony-stimulating factor) but increased amounts of a proinflammatory cytokine (tumor necrosis factor alpha), chemotactic cytokines (MDC, MCP-1, GRO, and fractalkine), and growth-promoting cytokines (PDGFBB/AA, VEGF, and EGF) as compared to ILI. CONCLUSIONS: Severe influenza cases showed a delay in the peripheral immune activation that likely led prolonged inflammation, compared with mild influenza cases. Twit Text FOAVip Severe Influenza Is Characterized by Prolonged Immune Activation: Results From the SHIVERS Cohort Study ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=29112724 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29112724 #FOAvip English Wikipedia <ref>{{Cite pmid|29112724}}</ref> Severe Influenza Is Characterized by Prolonged Immune Activation: Results From the SHIVERS Cohort Study #MMPMID29112724 Wong SS; Oshansky CM; Guo XJ; Ralston J; Wood T; Seeds R; Newbern C; Waite B; Reynolds G; Widdowson MA; Huang QS; Webby RJ; Thomas PG J Infect Dis 2018[Jan]; 217 (2): 245-256 PMID29112724show ga BACKGROUND: The immunologic factors underlying severe influenza are poorly understood. To address this, we compared the immune responses of influenza-confirmed hospitalized individuals with severe acute respiratory illness (SARI) to those of nonhospitalized individuals with influenza-like illness (ILI). METHODS: Peripheral blood lymphocytes were collected from 27 patients with ILI and 27 with SARI, at time of enrollment and then 2 weeks later. Innate and adaptive cellular immune responses were assessed by flow cytometry, and serum cytokine levels were assessed by a bead-based assay. RESULTS: During the acute phase, SARI was associated with significantly reduced numbers of circulating myeloid dendritic cells, CD192+ monocytes, and influenza virus-specific CD8+ and CD4+ T cells as compared to ILI. By the convalescent phase, however, most SARI cases displayed continued immune activation characterized by increased numbers of CD16+ monocytes and proliferating, and influenza virus-specific, CD8+ T cells as compared to ILI cases. SARI was also associated with reduced amounts of cytokines that regulate T-cell responses (ie, interleukin 4, interleukin 13, interleukin 12, interleukin 10, and tumor necrosis factor beta) and hematopoiesis (interleukin 3 and granulocyte-macrophage colony-stimulating factor) but increased amounts of a proinflammatory cytokine (tumor necrosis factor alpha), chemotactic cytokines (MDC, MCP-1, GRO, and fractalkine), and growth-promoting cytokines (PDGFBB/AA, VEGF, and EGF) as compared to ILI. CONCLUSIONS: Severe influenza cases showed a delay in the peripheral immune activation that likely led prolonged inflammation, compared with mild influenza cases. |*Adaptive Immunity[MESH] |*Immunity, Cellular[MESH] |*Immunity, Innate[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Child[MESH] |Cohort Studies[MESH] |Cytokines/blood[MESH] |Dendritic Cells/immunology[MESH] |Female[MESH] |Humans[MESH] |Inflammation/*immunology/*pathology[MESH] |Influenza, Human/*immunology/*pathology[MESH] |Lymphocytes/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/immunology[MESH]Severe Influenza Is Characterized by Prolonged Immune Activation: Resu(epmc).pdf DeepDyve Pubget Overpricing