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10.1681/ASN.2017030267 http://scihub22266oqcxt.onion/10.1681/ASN.2017030267 29093028!5748908!29093028     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2018 ; 29 (1): 335-348 Nephropedia Template TP {{tp|p=29093028|t=2018. Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes |pdf=|usr=}}{{29093028}} gab.com Text Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=29093028 #FOAvip Magnesium (Mg(2+)) homeostasis is critical for metabolism. However, the genetic determinants of the renal handling of Mg(2+), which is crucial for Mg(2+) homeostasis, and the potential influence on metabolic traits in the general population are unknown. We obtained plasma and urine parameters from 9099 individuals from seven cohorts, and conducted a genome-wide meta-analysis of Mg(2+) homeostasis. We identified two loci associated with urinary magnesium (uMg), rs3824347 (P=4.4x10(-13)) near TRPM6, which encodes an epithelial Mg(2+) channel, and rs35929 (P=2.1x10(-11)), a variant of ARL15, which encodes a GTP-binding protein. Together, these loci account for 2.3% of the variation in 24-hour uMg excretion. In human kidney cells, ARL15 regulated TRPM6-mediated currents. In zebrafish, dietary Mg(2+) regulated the expression of the highly conserved ARL15 ortholog arl15b, and arl15b knockdown resulted in renal Mg(2+) wasting and metabolic disturbances. Finally, ARL15 rs35929 modified the association of uMg with fasting insulin and fat mass in a general population. In conclusion, this combined observational and experimental approach uncovered a gene-environment interaction linking Mg(2+) deficiency to insulin resistance and obesity. Twit Text FOAVip Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=29093028 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29093028 #FOAvip English Wikipedia <ref>{{Cite pmid|29093028}}</ref> Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes #MMPMID29093028 Corre T; Arjona FJ; Hayward C; Youhanna S; de Baaij JHF; Belge H; Nagele N; Debaix H; Blanchard MG; Traglia M; Harris SE; Ulivi S; Rueedi R; Lamparter D; Mace A; Sala C; Lenarduzzi S; Ponte B; Pruijm M; Ackermann D; Ehret G; Baptista D; Polasek O; Rudan I; Hurd TW; Hastie ND; Vitart V; Waeber G; Kutalik Z; Bergmann S; Vargas-Poussou R; Konrad M; Gasparini P; Deary IJ; Starr JM; Toniolo D; Vollenweider P; Hoenderop JGJ; Bindels RJM; Bochud M; Devuyst O J Am Soc Nephrol 2018[Jan]; 29 (1): 335-348 PMID29093028show ga Magnesium (Mg(2+)) homeostasis is critical for metabolism. However, the genetic determinants of the renal handling of Mg(2+), which is crucial for Mg(2+) homeostasis, and the potential influence on metabolic traits in the general population are unknown. We obtained plasma and urine parameters from 9099 individuals from seven cohorts, and conducted a genome-wide meta-analysis of Mg(2+) homeostasis. We identified two loci associated with urinary magnesium (uMg), rs3824347 (P=4.4x10(-13)) near TRPM6, which encodes an epithelial Mg(2+) channel, and rs35929 (P=2.1x10(-11)), a variant of ARL15, which encodes a GTP-binding protein. Together, these loci account for 2.3% of the variation in 24-hour uMg excretion. In human kidney cells, ARL15 regulated TRPM6-mediated currents. In zebrafish, dietary Mg(2+) regulated the expression of the highly conserved ARL15 ortholog arl15b, and arl15b knockdown resulted in renal Mg(2+) wasting and metabolic disturbances. Finally, ARL15 rs35929 modified the association of uMg with fasting insulin and fat mass in a general population. In conclusion, this combined observational and experimental approach uncovered a gene-environment interaction linking Mg(2+) deficiency to insulin resistance and obesity. |ADP-Ribosylation Factors/*genetics[MESH] |Adiposity/genetics[MESH] |Animals[MESH] |GTP-Binding Proteins/genetics[MESH] |Gene-Environment Interaction[MESH] |Genome-Wide Association Study[MESH] |Homeostasis/*genetics[MESH] |Humans[MESH] |Insulin Resistance/genetics[MESH] |Insulin/blood[MESH] |Kidney/*metabolism[MESH] |Magnesium/administration & dosage/*blood/*urine[MESH] |Mice[MESH] |Obesity/genetics[MESH] |Phenotype[MESH] |Polymorphism, Single Nucleotide[MESH] |RNA, Messenger/metabolism[MESH] |TRPM Cation Channels/*genetics[MESH] |Zebrafish[MESH]Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Home(epmc).pdf DeepDyve Pubget Overpricing