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10.1111/ctr.13146

http://scihub22266oqcxt.onion/10.1111/ctr.13146
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29090481!7162290!29090481
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suck abstract from ncbi


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pmid29090481      Clin+Transplant 2018 ; 32 (1): ä
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  • Utility of flexible bronchoscopy with polymerase chain reaction in the diagnosis and management of pulmonary infiltrates in allogeneic HSCT patients #MMPMID29090481
  • Tang FF; Zhao XS; Xu LP; Zhang XH; Chen YH; Mo XD; Liu KY; Huang XJ
  • Clin Transplant 2018[Jan]; 32 (1): ä PMID29090481show ga
  • OBJECTIVES: Pulmonary infiltrates in allogeneic hematopoietic stem cell transplant (allo-HSCT) patients are potentially life-threatening and require early diagnosis and treatment. We aimed to retrospectively explore the clinical efficacy of polymerase chain reaction (PCR) in conjunction with flexible bronchoscopy (FB) in allo-HSCT patients with pulmonary infiltrates. PATIENTS AND METHODS: We retrospectively reviewed all patients undergoing FB after allo-HSCT at the Peking University Institute of Hematology from January 2013 to December 2016. We used PCR to detect various viruses in FB specimens, particularly for 27 viruses. RESULTS: One hundred forty-nine diagnostic FBs were performed in 130 patients. The overall diagnostic yield was 58%. Eighty-nine percent of the patients with a positive FB result were diagnosed with a pulmonary infection. Viruses were the most common infectious diagnosis (70%), followed by fungi (48%), bacteria (38%), and Pneumocystis jirovecii (12%). Multivariate analyses showed that a chest computed tomography (CT) finding of diffuse pulmonary infiltrates (P = .012) and positive results in assisted microbiological and serological analyses (P = .000) predicted a positive FB result. FB results prompted a treatment modification in 61% of cases. CONCLUSIONS: FB in conjunction with PCR is efficient in the rapid diagnosis and management of pulmonary infiltrates in allo-HSCT patients.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Anti-Infective Agents/*therapeutic use[MESH]
  • |Bronchoscopy/*methods[MESH]
  • |Child[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Hematologic Neoplasms/*therapy[MESH]
  • |Hematopoietic Stem Cell Transplantation/*adverse effects[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Polymerase Chain Reaction/*methods[MESH]
  • |Prognosis[MESH]
  • |Respiratory Tract Infections/*diagnosis/*drug therapy/etiology[MESH]
  • |Retrospective Studies[MESH]


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