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10.1111/adb.12569 http://scihub22266oqcxt.onion/10.1111/adb.12569 29082582/?report=reader!6584945!29082582     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Addict+Biol 2018 ; 23 (5): 1145-1159 Nephropedia Template TP {{tp|p=29082582|t=2018. Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations |pdf=|usr=}}{{29082582}} gab.com Text Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations JO: Addict Biol http://www.kidney.de/pget.php?&tw=1&pmid=29082582 #FOAvip Excessive alcohol use is extremely prevalent in the United States, particularly among trauma-exposed individuals. While several studies have examined genetic influences on alcohol use and related problems, this has not been studied in the context of trauma-exposed populations. We report results from a genome-wide association study of alcohol consumption and associated problems as measured by the alcohol use disorders identification test (AUDIT) in a trauma-exposed cohort. Results indicate a genome-wide significant association between total AUDIT score and rs1433375 [N = 1036, P = 2.61 x 10(-8) (dominant model), P = 7.76 x 10(-8) (additive model)], an intergenic single-nucleotide polymorphism located 323 kb upstream of the sodium channel and clathrin linker 1 (SCLT1) at 4q28. rs1433375 was also significant in a meta-analysis of two similar, but independent, cohorts (N = 1394, P = 0.0004), the Marine Resiliency Study and Systems Biology PTSD Biomarkers Consortium. Functional analysis indicated that rs1433375 was associated with SCLT1 gene expression and cortical-cerebellar functional connectivity measured via resting state functional magnetic resonance imaging. Together, findings suggest a role for sodium channel regulation and cerebellar functioning in alcohol use behavior. Identifying mechanisms underlying risk for problematic alcohol use in trauma-exposed populations is critical for future treatment and prevention efforts. Twit Text FOAVip Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations ????Addict Biol http://www.kidney.de/pget.php?&tw=1&pmid=29082582 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29082582 #FOAvip English Wikipedia <ref>{{Cite pmid|29082582}}</ref> Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations #MMPMID29082582 Almli LM; Lori A; Meyers JL; Shin J; Fani N; Maihofer AX; Nievergelt CM; Smith AK; Mercer KB; Kerley K; Leveille JM; Feng H; Abu-Amara D; Flory JD; Yehuda R; Marmar CR; Baker DG; Bradley B; Koenen KC; Conneely KN; Ressler KJ Addict Biol 2018[Sep]; 23 (5): 1145-1159 PMID29082582show ga Excessive alcohol use is extremely prevalent in the United States, particularly among trauma-exposed individuals. While several studies have examined genetic influences on alcohol use and related problems, this has not been studied in the context of trauma-exposed populations. We report results from a genome-wide association study of alcohol consumption and associated problems as measured by the alcohol use disorders identification test (AUDIT) in a trauma-exposed cohort. Results indicate a genome-wide significant association between total AUDIT score and rs1433375 [N = 1036, P = 2.61 x 10(-8) (dominant model), P = 7.76 x 10(-8) (additive model)], an intergenic single-nucleotide polymorphism located 323 kb upstream of the sodium channel and clathrin linker 1 (SCLT1) at 4q28. rs1433375 was also significant in a meta-analysis of two similar, but independent, cohorts (N = 1394, P = 0.0004), the Marine Resiliency Study and Systems Biology PTSD Biomarkers Consortium. Functional analysis indicated that rs1433375 was associated with SCLT1 gene expression and cortical-cerebellar functional connectivity measured via resting state functional magnetic resonance imaging. Together, findings suggest a role for sodium channel regulation and cerebellar functioning in alcohol use behavior. Identifying mechanisms underlying risk for problematic alcohol use in trauma-exposed populations is critical for future treatment and prevention efforts. |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Alcoholism/*complications/*genetics/physiopathology[MESH] |Black or African American/statistics & numerical data[MESH] |Brain/physiopathology[MESH] |Cohort Studies[MESH] |Female[MESH] |Genome-Wide Association Study/*methods[MESH] |Georgia[MESH] |Humans[MESH] |Magnetic Resonance Imaging/methods[MESH] |Male[MESH] |Middle Aged[MESH] |Polymorphism, Single Nucleotide/genetics[MESH] |Sodium Channels/*genetics[MESH] |Stress Disorders, Post-Traumatic/*complications[MESH]Problematic alcohol use associates with sodium channel and clathrin li(epmc).pdf DeepDyve Pubget Overpricing