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10.3762/bjoc.13.190

http://scihub22266oqcxt.onion/10.3762/bjoc.13.190
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29062414!5629381!29062414
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suck abstract from ncbi

pmid29062414      Beilstein+J+Org+Chem 2017 ; 13 (?): 1957-1962
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  • High-speed vibration-milling-promoted synthesis of symmetrical frameworks containing two or three pyrrole units #MMPMID29062414
  • Leonardi M; Villacampa M; Menendez JC
  • Beilstein J Org Chem 2017[]; 13 (?): 1957-1962 PMID29062414show ga
  • The pseudo-five-component reaction between beta-dicarbonyl compounds (2 molecules), diamines and alpha-iodoketones (2 molecules), prepared in situ from aryl ketones, was performed efficiently under mechanochemical conditions involving high-speed vibration milling with a single zirconium oxide ball. This reaction afforded symmetrical frameworks containing two pyrrole or fused pyrrole units joined by a spacer, which are of interest in the exploration of chemical space for drug discovery purposes. The method was also extended to the synthesis of one compound containing three identical pyrrole fragments via a pseudo-seven-component reaction. Access to compounds having a double bond in their spacer chain was achieved by a different approach involving the homodimerization of 1-allyl- or 1-homoallylpyrroles by application of cross-metathesis chemistry.
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