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10.1002/biof.1390 http://scihub22266oqcxt.onion/10.1002/biof.1390 29048780!ä!29048780 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biofactors 2017 ; 43 (6): 836-846 Nephropedia Template TP {{tp|p=29048780|t=2017. Magnesium isoglycyrrhizinate promotes the activated hepatic stellate cells apoptosis via endoplasmic reticulum stress and ameliorates fibrogenesis in vitro and in vivo |pdf=|usr=}}{{29048780}} gab.com Text Magnesium isoglycyrrhizinate promotes the activated hepatic stellate cells apoptosis via endoplasmic reticulum stress and ameliorates fibrogenesis in vitro and in vivo JO: Biofactors http://www.kidney.de/pget.php?&tw=1&pmid=29048780 #FOAvip Varied pathogenetic elements have been touched upon the liver fibrosis, including inflammatory, stress, apoptosis and unfolded proteins aggregation. Magnesium Isoglycyrrhizinate (MgIG) has been accepted to be a neuroprotective effect, hepatoprotective and anti-inflammatory molecule. In our vitro researches, MgIG was considered to activate hepatic stellate cells (HSCs) apoptosis by promoting endoplasmic reticulum stress (ERS) detrimental response to a certain extent. Consequently, MgIG showed its potential therapeutic capacity in fibrogenesis and counteracted the pathogenetic aspects, which were involved in integrating current treatments correcting liver fibrosis. In addition, we further verificated the behavior and pathogenic mechanisms in the CCl(4) -induced liver fibrosis in male mice. What surprised us was that with the treatment of MgIG caused the activation of ERS and resisted the activated HSCs in the protective effects on liver damage. We found MgIG significantly promoted the apoptosis of activated HSCs and protected the CCl(4) -induced liver fibrosis. Main molecules came down to the unfolded protein response signaling pathway. Furthermore, MgIG inhibited the levels of the downstream inflammatory cytokines, which were triggered by CCl(4) -induced liver fibrosis. Here, we reported that MgIG improved behavioral impairments induced by intraperitoneal injection of CCl(4) and decreased the expression of proinflammatory factor, which indicated the preserving effects on liver fibrosis. (c) 2017 BioFactors, 43(6):836-846, 2017. Twit Text FOAVip Magnesium isoglycyrrhizinate promotes the activated hepatic stellate cells apoptosis via endoplasmic reticulum stress and ameliorates fibrogenesis in vitro and in vivo ????Biofactors http://www.kidney.de/pget.php?&tw=1&pmid=29048780 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29048780 #FOAvip English Wikipedia <ref>{{Cite pmid|29048780}}</ref> Magnesium isoglycyrrhizinate promotes the activated hepatic stellate cells apoptosis via endoplasmic reticulum stress and ameliorates fibrogenesis in vitro and in vivo #MMPMID29048780 Bian M; Chen X; Zhang C; Jin H; Wang F; Shao J; Chen A; Zhang F; Zheng S Biofactors 2017[Nov]; 43 (6): 836-846 PMID29048780show ga Varied pathogenetic elements have been touched upon the liver fibrosis, including inflammatory, stress, apoptosis and unfolded proteins aggregation. Magnesium Isoglycyrrhizinate (MgIG) has been accepted to be a neuroprotective effect, hepatoprotective and anti-inflammatory molecule. In our vitro researches, MgIG was considered to activate hepatic stellate cells (HSCs) apoptosis by promoting endoplasmic reticulum stress (ERS) detrimental response to a certain extent. Consequently, MgIG showed its potential therapeutic capacity in fibrogenesis and counteracted the pathogenetic aspects, which were involved in integrating current treatments correcting liver fibrosis. In addition, we further verificated the behavior and pathogenic mechanisms in the CCl(4) -induced liver fibrosis in male mice. What surprised us was that with the treatment of MgIG caused the activation of ERS and resisted the activated HSCs in the protective effects on liver damage. We found MgIG significantly promoted the apoptosis of activated HSCs and protected the CCl(4) -induced liver fibrosis. Main molecules came down to the unfolded protein response signaling pathway. Furthermore, MgIG inhibited the levels of the downstream inflammatory cytokines, which were triggered by CCl(4) -induced liver fibrosis. Here, we reported that MgIG improved behavioral impairments induced by intraperitoneal injection of CCl(4) and decreased the expression of proinflammatory factor, which indicated the preserving effects on liver fibrosis. (c) 2017 BioFactors, 43(6):836-846, 2017. |Animals[MESH] |Anti-Inflammatory Agents/*pharmacology[MESH] |Apoptosis/*drug effects/genetics[MESH] |Carbon Tetrachloride[MESH] |Cell Line[MESH] |Cyclin D1/genetics/metabolism[MESH] |Cyclin E/genetics/metabolism[MESH] |Cyclin-Dependent Kinase 4/genetics/metabolism[MESH] |Cyclin-Dependent Kinase 6/genetics/metabolism[MESH] |Cyclin-Dependent Kinase Inhibitor p27/genetics/metabolism[MESH] |Endoplasmic Reticulum Stress/*drug effects[MESH] |Gene Expression Regulation[MESH] |Hepatic Stellate Cells/*drug effects/metabolism/pathology[MESH] |Liver Cirrhosis/chemically induced/*drug therapy/genetics/metabolism[MESH] |Liver/drug effects/metabolism/pathology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred ICR[MESH] |Oncogene Proteins/genetics/metabolism[MESH] |Saponins/*pharmacology[MESH] |Signal Transduction[MESH] |Triterpenes/*pharmacology[MESH] |Unfolded Protein Response/drug effects[MESH]Magnesium isoglycyrrhizinate promotes the activated hepatic stellate c(epmc).pdf DeepDyve Pubget Overpricing