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10.1042/CS20171265 http://scihub22266oqcxt.onion/10.1042/CS20171265 29021222!ä!29021222 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Sci+(Lond) 2017 ; 131 (22): 2745-2752 Nephropedia Template TP {{tp|p=29021222|t=2017. The perivascular pathways for influx of cerebrospinal fluid are most efficient in the midbrain |pdf=|usr=}}{{29021222}} gab.com Text The perivascular pathways for influx of cerebrospinal fluid are most efficient in the midbrain JO: Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=29021222 #FOAvip Although there are no conventional lymphatic vessels in the brain, fluid and solutes drain along basement membranes (BMs) of cerebral capillaries and arteries towards the subarachnoid space and cervical lymph nodes. Convective influx/glymphatic entry of the cerebrospinal fluid (CSF) into the brain parenchyma occurs along the pial-glial BMs of arteries. This project tested the hypotheses that pial-glial BM of arteries are thicker in the midbrain, allowing more glymphatic entry of CSF. The in vivo MRI and PET images were obtained from a 4.2-year-old dog, whereas the post-mortem electron microscopy was performed in a 12-year-old dog. We demonstrated a significant increase in the thickness of the pial-glial BM in the midbrain compared with the same BM in different regions of the brain and an increase in the convective influx of fluid from the subarachnoid space. These results are highly significant for the intrathecal drug delivery into the brain, indicating that the midbrain is better equipped for convective influx/glymphatic entry of the CSF. Twit Text FOAVip The perivascular pathways for influx of cerebrospinal fluid are most efficient in the midbrain ????Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=29021222 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29021222 #FOAvip English Wikipedia <ref>{{Cite pmid|29021222}}</ref> The perivascular pathways for influx of cerebrospinal fluid are most efficient in the midbrain #MMPMID29021222 Dobson H; Sharp MM; Cumpsty R; Criswell TP; Wellman T; Finucane C; Sullivan JM; Weller RO; Verma A; Carare RO Clin Sci (Lond) 2017[Nov]; 131 (22): 2745-2752 PMID29021222show ga Although there are no conventional lymphatic vessels in the brain, fluid and solutes drain along basement membranes (BMs) of cerebral capillaries and arteries towards the subarachnoid space and cervical lymph nodes. Convective influx/glymphatic entry of the cerebrospinal fluid (CSF) into the brain parenchyma occurs along the pial-glial BMs of arteries. This project tested the hypotheses that pial-glial BM of arteries are thicker in the midbrain, allowing more glymphatic entry of CSF. The in vivo MRI and PET images were obtained from a 4.2-year-old dog, whereas the post-mortem electron microscopy was performed in a 12-year-old dog. We demonstrated a significant increase in the thickness of the pial-glial BM in the midbrain compared with the same BM in different regions of the brain and an increase in the convective influx of fluid from the subarachnoid space. These results are highly significant for the intrathecal drug delivery into the brain, indicating that the midbrain is better equipped for convective influx/glymphatic entry of the CSF. |Animals[MESH] |Arteries/ultrastructure[MESH] |Basement Membrane/ultrastructure[MESH] |Cerebrospinal Fluid/*metabolism[MESH] |Dogs[MESH] |Endothelium/ultrastructure[MESH] |Magnetic Resonance Imaging[MESH] |Mesencephalon/*blood supply/ultrastructure[MESH] |Muscle, Smooth/ultrastructure[MESH] |Neuroglia/ultrastructure[MESH] |Pia Mater/ultrastructure[MESH] |Positron-Emission Tomography[MESH]The perivascular pathways for influx of cerebrospinal fluid are most e(epmc).pdf DeepDyve Pubget Overpricing