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Significance of hydrogen sulfide in sepsis-induced myocardial injury in rats #MMPMID28962136
Li X; Cheng Q; Li J; He Y; Tian P; Xu C
Exp Ther Med 2017[Sep]; 14 (3): 2153-2161 PMID28962136show ga
Sepsis-induced myocardial injury is a detrimental disorder for intensive care medicine due to its high rates of morbidity and mortality. Data suggest that nuclear factor (NF)-kappaB serves a critical role in the pathogenesis of myocardial injury. Hydrogen sulfide (H(2)S) serves an important role in the physiology and pathophysiology of regulatory mechanisms, particularly during an inflammatory reaction. However, the relationship between NF-kappaB and H(2)S in sepsis-induced myocardial injury is not well understood, and the underlying mechanisms remain unclear. In the present study, 60 male Sprague Dawley rats were randomly divided into the following six groups: A sham group, cecal ligation and puncture (CLP) group, sham + propargylglycine (PAG) group, CLP + PAG group, sham + sodium hydrosulfide (NaHS) group and CLP + NaHS group, with 10 rats in each group. The rats in all groups were sacrificed 12 h after surgery for sample collection. Compared with the sham group, it was observed that the concentrations of Creatine Kinase-MB (CK-MB) and cardiac troponin I (cTnI) in the serum, and pathological scores of myocardial tissue were significantly increased in the CLP, CLP + NaHS and CLP + PAG groups (P<0.05). The pathological scores and concentrations of CK-MB and cTnI were significantly higher in the CLP + PAG group (P<0.05) and significantly lower in the CLP + NaHS group (P<0.05) when compared with the CLP group. The expression of cystathionine-gamma-lyase (CSE) mRNA and content of interleukin (IL)-10 were significantly higher in the CLP group compared with the CLP + PAG group (P<0.05), while the expression of myocardial NF-kappaB and content of tumor necrosis factor (TNF)-alpha in the CLP group were significantly lowered compared with the CLP + PAG group (P<0.05). The expression of NF-kappaB and content of TNF-alpha were significantly increased in the CLP group when compared with the CLP + NaHS group (P<0.05), while the content of myocardial IL-10 in the CLP group was significantly lower than in the CLP + NaHS group (P<0.05). In conclusion, H(2)S acted as an anti-inflammatory cytokine and biomarker in sepsis-induced myocardial injury. Furthermore, H(2)S may downregulate the NF-kappaB subunit p65 to mediate inflammatory responses. The present data suggest that myocardial injury in sepsis may be relieved through the regulation of H(2)S expression, and provide an experimental basis for the treatment of sepsis patients presenting with myocardial injury. In addition, myocardial injury in sepsis may be identified by monitoring changes in the expression of H(2)S.
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Exp+Ther+Med 2017 ; 14 (3): 2153-2161
