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10.1080/19420889.2017.1338990 http://scihub22266oqcxt.onion/10.1080/19420889.2017.1338990 28919938!5595415!28919938     free     free     free       Commun+Integr+Biol 2017 ; 10 (4): e1338990 Nephropedia Template TP {{tp|p=28919938|t=2017. Keep it on the edge: The post-mitotic midbody as a polarity signal unit |pdf=|usr=}}{{28919938}} gab.com Text Keep it on the edge: The post-mitotic midbody as a polarity signal unit JO: Commun Integr Biol http://www.kidney.de/pget.php?&tw=1&pmid=28919938 #FOAvip The maintenance of the epithelial architecture during tissue proliferation is achieved by apical positioning of the midbody after cell division. Consequently, midbody mislocalization contributes to epithelial architecture disruption, a fundamental event during epithelial tumorigenesis. Studies in 3D polarized epithelial MDCK or Caco2 cell models, where midbody misplacement leads to multiple ectopic but fully polarized lumen-containing cysts, revealed that this phenotype can be caused by 2 different scenarios: the loss of mitotic spindle orientation or the loss of asymmetric abscission. In addition, we have recently proposed a third cellular mechanism where the midbody mislocalization is achieved through cytokinesis acceleration driven by the cancer-promoting phosphatase of regenerating liver (PRL)-3. Here we critically review these findings, and we furthermore present new data indicating that midbodies themselves might act as signal unit for polarization since they can infer apical characteristics to a basal membrane. Twit Text FOAVip Keep it on the edge: The post-mitotic midbody as a polarity signal unit ????Commun Integr Biol http://www.kidney.de/pget.php?&tw=1&pmid=28919938 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28919938 #FOAvip English Wikipedia <ref>{{Cite pmid|28919938}}</ref> Keep it on the edge: The post-mitotic midbody as a polarity signal unit #MMPMID28919938 Lujan P; Rubio T; Varsano G; Kohn M Commun Integr Biol 2017[]; 10 (4): e1338990 PMID28919938show ga The maintenance of the epithelial architecture during tissue proliferation is achieved by apical positioning of the midbody after cell division. Consequently, midbody mislocalization contributes to epithelial architecture disruption, a fundamental event during epithelial tumorigenesis. Studies in 3D polarized epithelial MDCK or Caco2 cell models, where midbody misplacement leads to multiple ectopic but fully polarized lumen-containing cysts, revealed that this phenotype can be caused by 2 different scenarios: the loss of mitotic spindle orientation or the loss of asymmetric abscission. In addition, we have recently proposed a third cellular mechanism where the midbody mislocalization is achieved through cytokinesis acceleration driven by the cancer-promoting phosphatase of regenerating liver (PRL)-3. Here we critically review these findings, and we furthermore present new data indicating that midbodies themselves might act as signal unit for polarization since they can infer apical characteristics to a basal membrane. ?Keep it on the edge: The post-mitotic midbody as a polarity signal uni(epmc).pdf DeepDyve Pubget Overpricing