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10.1016/j.mehy.2017.08.014 http://scihub22266oqcxt.onion/10.1016/j.mehy.2017.08.014 28915968!ä!28915968 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Hypotheses 2017 ; 107 (ä): 74-77 Nephropedia Template TP {{tp|p=28915968|t=2017. Magnesium to counteract elastin degradation and vascular calcification in chronic obstructive pulmonary disease |pdf=|usr=}}{{28915968}} gab.com Text Magnesium to counteract elastin degradation and vascular calcification in chronic obstructive pulmonary disease JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=28915968 #FOAvip Accelerated elastin degradation is an important pathogenic mechanism in chronic obstructive pulmonary disease (COPD) leading to irreversible lung function loss and cardiovascular comorbidities. The rate of elastin breakdown is a predictor of mortality in patients with COPD. Decelerating elastinolysis might be an attractive therapeutic target in this debilitating condition. Vascular calcification starts in the elastin network of the arterial wall and is enhanced in patients with COPD. Elastin calcification is accompanied by an upregulation of matrix metalloproteinase gene expression and consequently a shift in the elastase/anti-elastase balance towards degradation. Magnesium can be regarded as a natural calcium antagonist and has the proven ability to ameliorate vascular calcification. Furthermore, an animal study has suggested that magnesium deficiency promotes elastin degradation. I hypothesize that inhibiting elastin calcification by means of magnesium supplementation might counteract both vascular calcification and elastin degradation in COPD. This could potentially have a favorable impact on cardiovascular and respiratory related morbidity/mortality in patients with COPD. Twit Text FOAVip Magnesium to counteract elastin degradation and vascular calcification in chronic obstructive pulmonary disease ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=28915968 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28915968 #FOAvip English Wikipedia <ref>{{Cite pmid|28915968}}</ref> Magnesium to counteract elastin degradation and vascular calcification in chronic obstructive pulmonary disease #MMPMID28915968 Janssen R Med Hypotheses 2017[Sep]; 107 (ä): 74-77 PMID28915968show ga Accelerated elastin degradation is an important pathogenic mechanism in chronic obstructive pulmonary disease (COPD) leading to irreversible lung function loss and cardiovascular comorbidities. The rate of elastin breakdown is a predictor of mortality in patients with COPD. Decelerating elastinolysis might be an attractive therapeutic target in this debilitating condition. Vascular calcification starts in the elastin network of the arterial wall and is enhanced in patients with COPD. Elastin calcification is accompanied by an upregulation of matrix metalloproteinase gene expression and consequently a shift in the elastase/anti-elastase balance towards degradation. Magnesium can be regarded as a natural calcium antagonist and has the proven ability to ameliorate vascular calcification. Furthermore, an animal study has suggested that magnesium deficiency promotes elastin degradation. I hypothesize that inhibiting elastin calcification by means of magnesium supplementation might counteract both vascular calcification and elastin degradation in COPD. This could potentially have a favorable impact on cardiovascular and respiratory related morbidity/mortality in patients with COPD. |Animals[MESH] |Elastin/*metabolism[MESH] |Humans[MESH] |Magnesium Deficiency/etiology/metabolism[MESH] |Magnesium/administration & dosage/*therapeutic use[MESH] |Models, Biological[MESH] |Proteolysis/drug effects[MESH] |Pulmonary Disease, Chronic Obstructive/complications/*drug therapy/metabolism[MESH] |Renal Insufficiency, Chronic/metabolism[MESH]Magnesium to counteract elastin degradation and vascular calcification(epmc).pdf DeepDyve Pubget Overpricing