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10.1097/TP.0000000000001941 http://scihub22266oqcxt.onion/10.1097/TP.0000000000001941 28885495!ä!28885495 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28885495&cmd=llinks): Failed to open stream: HTTP request failed! 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Isoglycyrrhizinate Magnesium Enhances Hepatoprotective Effect of FK506 on Ischemia-Reperfusion Injury Through HMGB1 Inhibition in a Rat Model of Liver Transplantation |pdf=|usr=}}{{28885495}} gab.com Text Isoglycyrrhizinate Magnesium Enhances Hepatoprotective Effect of FK506 on Ischemia-Reperfusion Injury Through HMGB1 Inhibition in a Rat Model of Liver Transplantation JO: Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=28885495 #FOAvip BACKGROUND: Ischemia-reperfusion injury after liver transplantation (LT) impairs graft function and affects prognosis of recipients. Isoglycyrrhizinate magnesium (Iso) is a hepatoprotective drug usually used after liver injury. In this study, we intended to explore whether Iso alone have protective effect after ischemia-reperfusion injury in a rat model of liver transplantation. We also aimed to study whether Iso could enhance the hepatoprotective effect of FK506 (tacrolimus) and underlying mechanism. METHODS: Rats after LT were treated with different concentration of FK506 with or without, Iso or lower-dose FK506 plus Iso. Alanine transaminase, aspartate transaminase, and albumin level were measured after 48 hours, 72 hours, and 7 days. A cell ischemic/reperfusion model was established to further study the mechanism of hepatoprotective effect of FK506 and Iso. RESULTS: Iso treatment alone had no effect on liver grafts after LT, but lower-dose FK506 + Iso was better for maintenance of liver function than lower-dose FK506 alone at 48 hours, 72 hours, and 7 days after LT. In terms of mechanism, FK506 induced autophagy which resulted in significantly reduced apoptosis and maintained proliferative potential. However, autophagy induced by FK506 also lead to high-mobility group box (HMGB) 1 release from nuclei, resulting in hepatocyte injury through triggering of p38 phosphorylation and chemokine release. Iso effectively inhibited the release of HMGB1 and downstream inflammatory cytokines. CONCLUSIONS: Iso could inhibit release of HMGB1 by FK506 and enhance the hepatoprotective effect of FK506 in rat LT. Combining Iso with FK506 would be promising for the patients after LT. Twit Text FOAVip Isoglycyrrhizinate Magnesium Enhances Hepatoprotective Effect of FK506 on Ischemia-Reperfusion Injury Through HMGB1 Inhibition in a Rat Model of Liver Transplantation ????Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=28885495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28885495 #FOAvip English Wikipedia <ref>{{Cite pmid|28885495}}</ref> Isoglycyrrhizinate Magnesium Enhances Hepatoprotective Effect of FK506 on Ischemia-Reperfusion Injury Through HMGB1 Inhibition in a Rat Model of Liver Transplantation #MMPMID28885495 Zhang W; Li F; Ye Y; Liu Y; Yu S; Cen C; Chen X; Zhou L; Tang X; Yu J; Zheng S Transplantation 2017[Dec]; 101 (12): 2862-2872 PMID28885495show ga BACKGROUND: Ischemia-reperfusion injury after liver transplantation (LT) impairs graft function and affects prognosis of recipients. Isoglycyrrhizinate magnesium (Iso) is a hepatoprotective drug usually used after liver injury. In this study, we intended to explore whether Iso alone have protective effect after ischemia-reperfusion injury in a rat model of liver transplantation. We also aimed to study whether Iso could enhance the hepatoprotective effect of FK506 (tacrolimus) and underlying mechanism. METHODS: Rats after LT were treated with different concentration of FK506 with or without, Iso or lower-dose FK506 plus Iso. Alanine transaminase, aspartate transaminase, and albumin level were measured after 48 hours, 72 hours, and 7 days. A cell ischemic/reperfusion model was established to further study the mechanism of hepatoprotective effect of FK506 and Iso. RESULTS: Iso treatment alone had no effect on liver grafts after LT, but lower-dose FK506 + Iso was better for maintenance of liver function than lower-dose FK506 alone at 48 hours, 72 hours, and 7 days after LT. In terms of mechanism, FK506 induced autophagy which resulted in significantly reduced apoptosis and maintained proliferative potential. However, autophagy induced by FK506 also lead to high-mobility group box (HMGB) 1 release from nuclei, resulting in hepatocyte injury through triggering of p38 phosphorylation and chemokine release. Iso effectively inhibited the release of HMGB1 and downstream inflammatory cytokines. CONCLUSIONS: Iso could inhibit release of HMGB1 by FK506 and enhance the hepatoprotective effect of FK506 in rat LT. Combining Iso with FK506 would be promising for the patients after LT. |*Liver Transplantation[MESH] |Alanine Transaminase/metabolism[MESH] |Animals[MESH] |Apoptosis/drug effects[MESH] |Aspartate Aminotransferases/metabolism[MESH] |Autophagy[MESH] |Cell Line[MESH] |HMGB1 Protein/*antagonists & inhibitors[MESH] |Hepatocytes/drug effects[MESH] |Humans[MESH] |Immunosuppressive Agents/pharmacology[MESH] |Liver Function Tests[MESH] |Liver/*drug effects[MESH] |Magnesium/*pharmacology[MESH] |Male[MESH] |Rats[MESH] |Rats, Inbred Lew[MESH] |Reperfusion Injury/*drug therapy[MESH] |Saponins/*pharmacology[MESH] |Tacrolimus/*pharmacology[MESH]Isoglycyrrhizinate Magnesium Enhances Hepatoprotective Effect of FK506(epmc).pdf DeepDyve Pubget Overpricing