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Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Alzheimers+Dis 2017 ; 60 (1): 183-200 Nephropedia Template TP
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Cerebrospinal Fluid Amyloid-beta 42, Total Tau and Phosphorylated Tau are Low in Patients with Normal Pressure Hydrocephalus: Analogies and Differences with Alzheimer s Disease #MMPMID28826180
J Alzheimers Dis 2017[]; 60 (1): 183-200 PMID28826180show ga
Co-existence of Alzheimer's disease (AD) in normal pressure hydrocephalus (NPH) is a frequent finding, thus a common pathophysiological basis between AD and NPH has been postulated. We measured CSF amyloid-beta 42 (Abeta42), total tau (t-tau), and phosphorylated tau (p-tau) concentrations in a sample of 294 patients with different types of dementia and 32 subjects without dementia. We then compared scores on neuropsychological tests of NPH patients with pathological and normal CSF Abeta42 values. Abeta42 levels were significantly lower in NPH than in control patients, with no significant differences between AD and NPH. On the contrary, t-tau and p-tau levels were significantly lower in NPH than in AD, with no differences between NPH and controls. NPH patients with pathological Abeta42 levels did not perform worse than NPH patients with normal Abeta42 levels in any cognitive domains. Our data seem to support the hypothesis of amyloid accumulation in brains of NPH patients. Nevertheless, amyloid does not seem to play a pathogenetic role in the development of cognitive deficits in NPH.
|Aged[MESH]
|Aged, 80 and over[MESH]
|Alzheimer Disease/*cerebrospinal fluid[MESH]
|Amyloid beta-Peptides/*cerebrospinal fluid[MESH]
|Chi-Square Distribution[MESH]
|Female[MESH]
|Humans[MESH]
|Hydrocephalus, Normal Pressure/*cerebrospinal fluid[MESH]