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10.1016/j.virol.2017.08.011 http://scihub22266oqcxt.onion/10.1016/j.virol.2017.08.011 28806616!5623651!28806616     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2017 ; 511 (ä): 40-48 Nephropedia Template TP {{tp|p=28806616|t=2017. Parvovirus B19 integration into human CD36+ erythroid progenitor cells |pdf=|usr=}}{{28806616}} gab.com Text Parvovirus B19 integration into human CD36+ erythroid progenitor cells JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=28806616 #FOAvip The pathogenic autonomous human parvovirus B19 (B19V) productively infects erythroid progenitor cells (EPCs). Functional similarities between B19V nonstructural protein (NS1), a DNA binding endonuclease, and the Rep proteins of Adeno-Associated Virus (AAV) led us to hypothesize that NS1 may facilitate targeted nicking of the human genome and B19 vDNA integration. We adapted an integration capture sequencing protocol (IC-Seq) to screen B19V infected human CD36+ EPCs for viral integrants, and discovered 40,000 unique B19V integration events distributed throughout the human genome. Computational analysis of integration patterns revealed strong correlations with gene intronic regions, H3K9me3 sites, and the identification of 41 base pair consensus sequence with an octanucleotide core motif. The octanucleotide core has homology to a single region of B19V, adjacent to the P6 promoter TATA box. We present the first direct evidence that B19V infection of erythroid progenitor cells disrupts the human genome and facilitates viral DNA integration. Twit Text FOAVip Parvovirus B19 integration into human CD36+ erythroid progenitor cells ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=28806616 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28806616 #FOAvip English Wikipedia <ref>{{Cite pmid|28806616}}</ref> Parvovirus B19 integration into human CD36+ erythroid progenitor cells #MMPMID28806616 Janovitz T; Wong S; Young NS; Oliveira T; Falck-Pedersen E Virology 2017[Nov]; 511 (ä): 40-48 PMID28806616show ga The pathogenic autonomous human parvovirus B19 (B19V) productively infects erythroid progenitor cells (EPCs). Functional similarities between B19V nonstructural protein (NS1), a DNA binding endonuclease, and the Rep proteins of Adeno-Associated Virus (AAV) led us to hypothesize that NS1 may facilitate targeted nicking of the human genome and B19 vDNA integration. We adapted an integration capture sequencing protocol (IC-Seq) to screen B19V infected human CD36+ EPCs for viral integrants, and discovered 40,000 unique B19V integration events distributed throughout the human genome. Computational analysis of integration patterns revealed strong correlations with gene intronic regions, H3K9me3 sites, and the identification of 41 base pair consensus sequence with an octanucleotide core motif. The octanucleotide core has homology to a single region of B19V, adjacent to the P6 promoter TATA box. We present the first direct evidence that B19V infection of erythroid progenitor cells disrupts the human genome and facilitates viral DNA integration. |*Virus Integration[MESH] |CD36 Antigens/analysis[MESH] |Cells, Cultured[MESH] |DNA-Binding Proteins/*metabolism[MESH] |DNA/*metabolism[MESH] |Endonucleases/*metabolism[MESH] |Erythroid Precursor Cells/chemistry/*virology[MESH] |Humans[MESH] |Parvovirus B19, Human/*physiology[MESH]Parvovirus B19 integration into human CD36+ erythroid progenitor cells(epmc).pdf DeepDyve Pubget Overpricing