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10.1016/j.kint.2017.04.011 http://scihub22266oqcxt.onion/10.1016/j.kint.2017.04.011 28760336!ä!28760336 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Int 2017 ; 92 (5): 1084-1099 Nephropedia Template TP {{tp|p=28760336|t=2017. Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats |pdf=|usr=}}{{28760336}} gab.com Text Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=28760336 #FOAvip Although magnesium has been shown to prevent vascular calcification in vitro, controlled in vivo studies in uremic animal models are limited. To determine whether dietary magnesium supplementation protects against the development of vascular calcification, 5/6 nephrectomized Wistar rats were fed diets with different magnesium content increasing from 0.1 to 1.1%. In one study we analyzed bone specimens from rats fed 0.1%, 0.3%, and 0.6% magnesium diets, and in another study we evaluated the effect of intraperitoneal magnesium on vascular calcification in 5/6 nephrectomized rats. The effects of magnesium on established vascular calcification were also evaluated in uremic rats fed on diets with either normal (0.1%) or moderately increased magnesium (0.6%) content. The increase in dietary magnesium resulted in a marked reduction in vascular calcification, together with improved mineral metabolism and renal function. Moderately elevated dietary magnesium (0.3%), but not high dietary magnesium (0.6%), improved bone homeostasis as compared to basal dietary magnesium (0.1%). Results of our study also suggested that the protective effect of magnesium on vascular calcification was not limited to its action as an intestinal phosphate binder since magnesium administered intraperitoneally also decreased vascular calcification. Oral magnesium supplementation also reduced blood pressure in uremic rats, and in vitro medium magnesium decreased BMP-2 and p65-NF-kappaB in TNF-alpha-treated human umbilical vein endothelial cells. Finally, in uremic rats with established vascular calcification, increasing dietary magnesium from 0.1% magnesium to 0.6% reduced the mortality rate from 52% to 28%, which was associated with reduced vascular calcification. Thus, increasing dietary magnesium reduced both vascular calcification and mortality in uremic rats. Twit Text FOAVip Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=28760336 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28760336 #FOAvip English Wikipedia <ref>{{Cite pmid|28760336}}</ref> Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats #MMPMID28760336 Diaz-Tocados JM; Peralta-Ramirez A; Rodriguez-Ortiz ME; Raya AI; Lopez I; Pineda C; Herencia C; Montes de Oca A; Vergara N; Steppan S; Pendon-Ruiz de Mier MV; Buendia P; Carmona A; Carracedo J; Alcala-Diaz JF; Frazao J; Martinez-Moreno JM; Canalejo A; Felsenfeld A; Rodriguez M; Aguilera-Tejero E; Almaden Y; Munoz-Castaneda JR Kidney Int 2017[Nov]; 92 (5): 1084-1099 PMID28760336show ga Although magnesium has been shown to prevent vascular calcification in vitro, controlled in vivo studies in uremic animal models are limited. To determine whether dietary magnesium supplementation protects against the development of vascular calcification, 5/6 nephrectomized Wistar rats were fed diets with different magnesium content increasing from 0.1 to 1.1%. In one study we analyzed bone specimens from rats fed 0.1%, 0.3%, and 0.6% magnesium diets, and in another study we evaluated the effect of intraperitoneal magnesium on vascular calcification in 5/6 nephrectomized rats. The effects of magnesium on established vascular calcification were also evaluated in uremic rats fed on diets with either normal (0.1%) or moderately increased magnesium (0.6%) content. The increase in dietary magnesium resulted in a marked reduction in vascular calcification, together with improved mineral metabolism and renal function. Moderately elevated dietary magnesium (0.3%), but not high dietary magnesium (0.6%), improved bone homeostasis as compared to basal dietary magnesium (0.1%). Results of our study also suggested that the protective effect of magnesium on vascular calcification was not limited to its action as an intestinal phosphate binder since magnesium administered intraperitoneally also decreased vascular calcification. Oral magnesium supplementation also reduced blood pressure in uremic rats, and in vitro medium magnesium decreased BMP-2 and p65-NF-kappaB in TNF-alpha-treated human umbilical vein endothelial cells. Finally, in uremic rats with established vascular calcification, increasing dietary magnesium from 0.1% magnesium to 0.6% reduced the mortality rate from 52% to 28%, which was associated with reduced vascular calcification. Thus, increasing dietary magnesium reduced both vascular calcification and mortality in uremic rats. |*Dietary Supplements[MESH] |Animals[MESH] |Bone and Bones/*metabolism[MESH] |Chelating Agents/administration & dosage[MESH] |Disease Models, Animal[MESH] |Human Umbilical Vein Endothelial Cells[MESH] |Humans[MESH] |Magnesium/*administration & dosage/blood[MESH] |Male[MESH] |Nephrectomy[MESH] |Phosphates/*metabolism[MESH] |Rats[MESH] |Rats, Wistar[MESH] |Uremia/blood/*complications/diet therapy[MESH]Dietary magnesium supplementation prevents and reverses vascular and s(epmc).pdf DeepDyve Pubget Overpricing