Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41598-017-07017-x http://scihub22266oqcxt.onion/10.1038/s41598-017-07017-x 28751735!5532246!28751735     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28751735&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Sci+Rep 2017 ; 7 (1): 6694 Nephropedia Template TP {{tp|p=28751735|t=2017. Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia |pdf=|usr=}}{{28751735}} gab.com Text Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28751735 #FOAvip In preeclampsia, the serum levels of transthyretin, a carrier protein for thyroxine, are elevated. Transthyretin isolated from preeclamptic serum is also aggregated and can induce preeclampsia-like symptoms in pregnant IL10(-/-) mice. Using western blotting, immunofluorescence, ELISA and qRT-PCR, we investigated the production of transthyretin by preeclamptic placentae and whether transthyretin is carried into the maternal circulation via placental extracellular vesicles. Both total and aggregated transthyretin were present in higher levels in preeclamptic placentae compared to normotensive placentae (p < 0.05, n = 7), however the levels of transythretin mRNA were not significantly different (n = 8). Preeclamptic placentae secreted similar levels of total transthyretin compared to normotensive placentae (2352 +/- 2949 ng/mL vs. 3250 +/- 1864 ng/mL, mean +/- SD, p > 0.05, n = 8), however in preeclampsia, a significant proportion is vesicle-associated (~48% vs 0%). Increased levels of aggregated transthyretin were specifically associated to preeclamptic nano-vesicles (p < 0.02, n = 8). This study showed that the placenta actively produces transthyretin and in preeclampsia, a significant amount is extruded into the maternal circulation via placental exracellular vesicles. The increased aggregation of transthyretin in preeclampsia occurs at the post-transcriptional level and while preeclamptic nano-vesicles may be removing a toxic aggregated protein from the placenta, they may also be delivering aggregated transthyretin to specific maternal organs, contributing to the pathogenesis of preeclampsia. Twit Text FOAVip Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28751735 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28751735 #FOAvip English Wikipedia <ref>{{Cite pmid|28751735}}</ref> Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia #MMPMID28751735 Tong M; Cheng SB; Chen Q; DeSousa J; Stone PR; James JL; Chamley LW; Sharma S Sci Rep 2017[Jul]; 7 (1): 6694 PMID28751735show ga In preeclampsia, the serum levels of transthyretin, a carrier protein for thyroxine, are elevated. Transthyretin isolated from preeclamptic serum is also aggregated and can induce preeclampsia-like symptoms in pregnant IL10(-/-) mice. Using western blotting, immunofluorescence, ELISA and qRT-PCR, we investigated the production of transthyretin by preeclamptic placentae and whether transthyretin is carried into the maternal circulation via placental extracellular vesicles. Both total and aggregated transthyretin were present in higher levels in preeclamptic placentae compared to normotensive placentae (p < 0.05, n = 7), however the levels of transythretin mRNA were not significantly different (n = 8). Preeclamptic placentae secreted similar levels of total transthyretin compared to normotensive placentae (2352 +/- 2949 ng/mL vs. 3250 +/- 1864 ng/mL, mean +/- SD, p > 0.05, n = 8), however in preeclampsia, a significant proportion is vesicle-associated (~48% vs 0%). Increased levels of aggregated transthyretin were specifically associated to preeclamptic nano-vesicles (p < 0.02, n = 8). This study showed that the placenta actively produces transthyretin and in preeclampsia, a significant amount is extruded into the maternal circulation via placental exracellular vesicles. The increased aggregation of transthyretin in preeclampsia occurs at the post-transcriptional level and while preeclamptic nano-vesicles may be removing a toxic aggregated protein from the placenta, they may also be delivering aggregated transthyretin to specific maternal organs, contributing to the pathogenesis of preeclampsia. |Adult[MESH] |Case-Control Studies[MESH] |Extracellular Vesicles/*metabolism[MESH] |Female[MESH] |Humans[MESH] |Nanoparticles/*chemistry[MESH] |Placenta/*metabolism[MESH] |Pre-Eclampsia/genetics/*metabolism[MESH] |Prealbumin/genetics/*metabolism[MESH] |Pregnancy[MESH] |Pregnancy Trimester, First/genetics[MESH] |Protein Aggregates[MESH]Aggregated transthyretin is specifically packaged into placental nano-(epmc).pdf DeepDyve Pubget Overpricing