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10.1177/1753425917718921 http://scihub22266oqcxt.onion/10.1177/1753425917718921 28691873!ä!28691873 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Innate+Immun 2017 ; 23 (5): 482-494 Nephropedia Template TP {{tp|p=28691873|t=2017. Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg(2+) infusion to dampen the stress response |pdf=|usr=}}{{28691873}} gab.com Text Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg(2+) infusion to dampen the stress response JO: Innate Immun http://www.kidney.de/pget.php?&tw=1&pmid=28691873 #FOAvip Our aim was to examine the effect of low-volume 0.9% NaCl adenosine, lidocaine and Mg(2+) (ALM) 'drip' on early immune-inflammatory activation after a single laparotomy with no further manipulation. Male Sprague-Dawley rats were anesthetized and randomly assigned to one of the groups, baseline, 1 h infusion 0.9% NaCl +/- ALM and metrics, 1 h infusion and 6-h metrics, and 6 h continuous infusion and metrics. Complete blood count, acid-base balance, systemic levels of IL-6 and IL-10, and coagulation status were measured. After 1 h, there was a disproportionate increase in circulating neutrophils between saline and ALM groups despite an identical 45% fall in lymphocytes. Disproportionate increases also occurred in platelet counts 1 h after surgery, and saline controls had increased respiratory alkalosis at 6 h with higher lactate. Systemic inflammation was also evident after 1 h in both groups (plasma IL-6 increase) and was amplified in saline-controls after 6 h. The ALM group increased anti-inflammatory cytokine IL-10. Surgery was not associated with acute coagulopathy; however, there were significant reductions in fibrinolysis. Following a single laparotomy, ALM infusion appeared to reduce stress-induced release of neutrophils and platelets into the circulation, and reduced acid-base disturbance. After 1 h, both groups had similar IL-6 levels, but ALM animals had increased IL-10, indicating improved inflammatory balance. The uncoupling of inflammation and coagulation activation but not fibrinolysis may offer a unique opportunity to investigate differential activation of innate immunity in response to sterile injury in this model. Twit Text FOAVip Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg(2+) infusion to dampen the stress response ????Innate Immun http://www.kidney.de/pget.php?&tw=1&pmid=28691873 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28691873 #FOAvip English Wikipedia <ref>{{Cite pmid|28691873}}</ref> Immune-inflammatory activation after a single laparotomy in a rat model: effect of adenosine, lidocaine and Mg(2+) infusion to dampen the stress response #MMPMID28691873 Davenport L; Letson HL; Dobson GP Innate Immun 2017[Jul]; 23 (5): 482-494 PMID28691873show ga Our aim was to examine the effect of low-volume 0.9% NaCl adenosine, lidocaine and Mg(2+) (ALM) 'drip' on early immune-inflammatory activation after a single laparotomy with no further manipulation. Male Sprague-Dawley rats were anesthetized and randomly assigned to one of the groups, baseline, 1 h infusion 0.9% NaCl +/- ALM and metrics, 1 h infusion and 6-h metrics, and 6 h continuous infusion and metrics. Complete blood count, acid-base balance, systemic levels of IL-6 and IL-10, and coagulation status were measured. After 1 h, there was a disproportionate increase in circulating neutrophils between saline and ALM groups despite an identical 45% fall in lymphocytes. Disproportionate increases also occurred in platelet counts 1 h after surgery, and saline controls had increased respiratory alkalosis at 6 h with higher lactate. Systemic inflammation was also evident after 1 h in both groups (plasma IL-6 increase) and was amplified in saline-controls after 6 h. The ALM group increased anti-inflammatory cytokine IL-10. Surgery was not associated with acute coagulopathy; however, there were significant reductions in fibrinolysis. Following a single laparotomy, ALM infusion appeared to reduce stress-induced release of neutrophils and platelets into the circulation, and reduced acid-base disturbance. After 1 h, both groups had similar IL-6 levels, but ALM animals had increased IL-10, indicating improved inflammatory balance. The uncoupling of inflammation and coagulation activation but not fibrinolysis may offer a unique opportunity to investigate differential activation of innate immunity in response to sterile injury in this model. |*Laparotomy[MESH] |Adenosine/chemistry/*therapeutic use[MESH] |Alkalosis, Respiratory[MESH] |Animals[MESH] |Blood Coagulation[MESH] |Blood Platelets/pathology[MESH] |Complex Mixtures/chemistry/*therapeutic use[MESH] |Disease Models, Animal[MESH] |Fibrinolysis[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Inflammation/*drug therapy/etiology[MESH] |Infusions, Intravenous[MESH] |Interleukin-10/blood[MESH] |Interleukin-6/blood[MESH] |Lidocaine/chemistry/*therapeutic use[MESH] |Magnesium/chemistry/*therapeutic use[MESH] |Male[MESH] |Neutrophils/pathology[MESH] |Postoperative Complications/*drug therapy[MESH] |Rats[MESH]Immune-inflammatory activation after a single laparotomy in a rat mode(epmc).pdf DeepDyve Pubget Overpricing