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10.1038/nrd.2017.22 http://scihub22266oqcxt.onion/10.1038/nrd.2017.22 28529316!5713640!28529316     free     free     free       Nat+Rev+Drug+Discov 2017 ; 16 (7): 487-511 Nephropedia Template TP {{tp|p=28529316|t=2017. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles |pdf=|usr=}}{{28529316}} gab.com Text Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles JO: Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=28529316 #FOAvip Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alterations in autophagy have been linked to clinically relevant conditions as diverse as cancer, neurodegeneration and cardiac disorders. Throughout the past decade, autophagy has attracted considerable attention as a target for the development of novel therapeutics. However, such efforts have not yet generated clinically viable interventions. In this Review, we discuss the therapeutic potential of autophagy modulators, analyse the obstacles that have limited their development and propose strategies that may unlock the full therapeutic potential of autophagy modulation in the clinic. Twit Text FOAVip Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles ????Nat Rev Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=28529316 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28529316 #FOAvip English Wikipedia <ref>{{Cite pmid|28529316}}</ref> Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles #MMPMID28529316 Galluzzi L; Bravo-San Pedro JM; Levine B; Green DR; Kroemer G Nat Rev Drug Discov 2017[Jul]; 16 (7): 487-511 PMID28529316show ga Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alterations in autophagy have been linked to clinically relevant conditions as diverse as cancer, neurodegeneration and cardiac disorders. Throughout the past decade, autophagy has attracted considerable attention as a target for the development of novel therapeutics. However, such efforts have not yet generated clinically viable interventions. In this Review, we discuss the therapeutic potential of autophagy modulators, analyse the obstacles that have limited their development and propose strategies that may unlock the full therapeutic potential of autophagy modulation in the clinic. |*Drug Design[MESH] |Animals[MESH] |Autophagy/*drug effects[MESH] |Heart Diseases/drug therapy/physiopathology[MESH] |Humans[MESH] |Molecular Targeted Therapy[MESH] |Neoplasms/*drug therapy/pathology[MESH]Pharmacological modulation of autophagy: therapeutic potential and per(epmc).pdf DeepDyve Pubget Overpricing