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10.1152/ajprenal.00688.2016 http://scihub22266oqcxt.onion/10.1152/ajprenal.00688.2016 28424213!ä!28424213 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2017 ; 313 (2): F339-F350 Nephropedia Template TP {{tp|p=28424213|t=2017. Magnesium improves cisplatin-mediated tumor killing while protecting against cisplatin-induced nephrotoxicity |pdf=|usr=}}{{28424213}} gab.com Text Magnesium improves cisplatin-mediated tumor killing while protecting against cisplatin-induced nephrotoxicity JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28424213 #FOAvip Approximately 30% of all cancer patients treated with cisplatin, a widely used broad-spectrum chemotherapeutic agent, experience acute kidney injury (AKI). Almost all patients receiving cisplatin have magnesium (Mg) losses, which are proposed to aggravate AKI. Currently, there are no methods to successfully treat or prevent cisplatin-AKI. Whereas Mg supplementation has been shown to reduce AKI in experimental models and several small clinical trials, the effects of Mg status on tumor outcomes in immunocompetent tumor-bearing mice and humans have not been investigated. The purpose of this study was to further examine the effects of Mg deficiency (+/-Mg supplementation) on cisplatin-mediated AKI and tumor killing in immunocompetent mice bearing CT26 colon tumors. Using a model where cisplatin alone (20 mg/kg cumulative dose) produced minimal kidney injury, Mg deficiency significantly worsened cisplatin-mediated AKI, as determined by biochemical markers (blood urea nitrogen and plasma creatinine) and histological renal changes, as well as markers of renal oxidative stress, inflammation, and apoptosis. By contrast, Mg supplementation blocked cisplatin-induced kidney injury. Using LLC-PK(1) renal epithelial cells, we observed that Mg deficiency or inhibition of Mg uptake significantly enhanced cisplatin-induced cytotoxicity, whereas Mg supplementation protected against cytotoxicity. However, neither Mg deficiency nor inhibition of Mg uptake impaired cisplatin-mediated killing of CT26 tumor cells in vitro. Mg deficiency was associated with significantly larger CT26 tumors in BALB/c mice when compared with normal-fed control mice, and Mg deficiency significantly reduced cisplatin-mediated tumor killing in vivo. Finally, Mg supplementation did not compromise cisplatin's anti-tumor efficacy in vivo. Twit Text FOAVip Magnesium improves cisplatin-mediated tumor killing while protecting against cisplatin-induced nephrotoxicity ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28424213 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28424213 #FOAvip English Wikipedia <ref>{{Cite pmid|28424213}}</ref> Magnesium improves cisplatin-mediated tumor killing while protecting against cisplatin-induced nephrotoxicity #MMPMID28424213 Kumar G; Solanki MH; Xue X; Mintz R; Madankumar S; Chatterjee PK; Metz CN Am J Physiol Renal Physiol 2017[Aug]; 313 (2): F339-F350 PMID28424213show ga Approximately 30% of all cancer patients treated with cisplatin, a widely used broad-spectrum chemotherapeutic agent, experience acute kidney injury (AKI). Almost all patients receiving cisplatin have magnesium (Mg) losses, which are proposed to aggravate AKI. Currently, there are no methods to successfully treat or prevent cisplatin-AKI. Whereas Mg supplementation has been shown to reduce AKI in experimental models and several small clinical trials, the effects of Mg status on tumor outcomes in immunocompetent tumor-bearing mice and humans have not been investigated. The purpose of this study was to further examine the effects of Mg deficiency (+/-Mg supplementation) on cisplatin-mediated AKI and tumor killing in immunocompetent mice bearing CT26 colon tumors. Using a model where cisplatin alone (20 mg/kg cumulative dose) produced minimal kidney injury, Mg deficiency significantly worsened cisplatin-mediated AKI, as determined by biochemical markers (blood urea nitrogen and plasma creatinine) and histological renal changes, as well as markers of renal oxidative stress, inflammation, and apoptosis. By contrast, Mg supplementation blocked cisplatin-induced kidney injury. Using LLC-PK(1) renal epithelial cells, we observed that Mg deficiency or inhibition of Mg uptake significantly enhanced cisplatin-induced cytotoxicity, whereas Mg supplementation protected against cytotoxicity. However, neither Mg deficiency nor inhibition of Mg uptake impaired cisplatin-mediated killing of CT26 tumor cells in vitro. Mg deficiency was associated with significantly larger CT26 tumors in BALB/c mice when compared with normal-fed control mice, and Mg deficiency significantly reduced cisplatin-mediated tumor killing in vivo. Finally, Mg supplementation did not compromise cisplatin's anti-tumor efficacy in vivo. |*Dietary Supplements[MESH] |Acute Kidney Injury/blood/chemically induced/pathology/*prevention & control[MESH] |Animals[MESH] |Antineoplastic Agents/*pharmacology/toxicity[MESH] |Apoptosis Regulatory Proteins/metabolism[MESH] |Apoptosis/drug effects[MESH] |Cell Death/drug effects[MESH] |Cell Line, Tumor[MESH] |Cisplatin/*pharmacology/toxicity[MESH] |Colorectal Neoplasms/*drug therapy/metabolism/pathology[MESH] |Cytoprotection[MESH] |Disease Models, Animal[MESH] |Dose-Response Relationship, Drug[MESH] |Female[MESH] |Inflammation Mediators/metabolism[MESH] |Kidney/*drug effects/metabolism/pathology[MESH] |LLC-PK1 Cells[MESH] |Magnesium Deficiency/complications/*drug therapy[MESH] |Magnesium Sulfate/*pharmacology[MESH] |Mice, Inbred BALB C[MESH] |Oxidative Stress/drug effects[MESH] |Swine[MESH] |Time Factors[MESH]Magnesium improves cisplatin-mediated tumor killing while protecting a(epmc).pdf DeepDyve Pubget Overpricing