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10.1002/jmv.24821 http://scihub22266oqcxt.onion/10.1002/jmv.24821 28390158!7159107!28390158     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2017 ; 89 (11): 2041-2046 Nephropedia Template TP {{tp|p=28390158|t=2017. Lithium chloride inhibits early stages of foot-and-mouth disease virus (FMDV) replication in vitro |pdf=|usr=}}{{28390158}} gab.com Text Lithium chloride inhibits early stages of foot-and-mouth disease virus (FMDV) replication in vitro JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=28390158 #FOAvip Foot-and-mouth disease virus (FMDV) causes an economically important and highly contagious disease of cloven-hoofed animals such as cattle, swine, and sheep. FMD vaccine is the traditional way to protect against the disease, which can greatly reduce its occurrence. However, the use of FMD vaccines to protect early infection is limited. Therefore, the alternative strategy of applying antiviral agents is required to control the spread of FMDV in outbreak situations. As previously reported, LiCl has obviously inhibition effects on a variety of viruses such as transmissible gastroenteritis virus (TGEV), infectious bronchitis coronavirus (IBV), and pseudorabies herpesvirus and EV-A71 virus. In this study, our findings were the first to demonstrate that LiCl inhibition of the FMDV replication. In this study, BHK-21 cell was dose-dependent with LiCl at various stages of FMDV. Virus titration assay was calculated by the 50% tissue culture infected dose (TCID(50) ) with the Reed and Muench method. The cytotoxicity assay of LiCl was performed by the CCK8 kit. The expression level of viral mRNA was measured by RT-qPCR. The results revealed LiCl can inhibit FMDV replication, but it cannot affect FMDV attachment stage and entry stage in the course of FMDV life cycle. Further studies confirmed that the LiCl affect the replication stage of FMDV, especially the early stages of FMDV replication. So LiCl has potential as an effective anti-FMDV drug. Therefore, LiCl may be an effective drug for the control of FMDV. Based on that, the mechanism of the antiviral effect of LiCl on FMDV infection is need to in-depth research in vivo. Twit Text FOAVip Lithium chloride inhibits early stages of foot-and-mouth disease virus (FMDV) replication in vitro ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=28390158 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28390158 #FOAvip English Wikipedia <ref>{{Cite pmid|28390158}}</ref> Lithium chloride inhibits early stages of foot-and-mouth disease virus (FMDV) replication in vitro #MMPMID28390158 Zhao FR; Xie YL; Liu ZZ; Shao JJ; Li SF; Zhang YG; Chang HY J Med Virol 2017[Nov]; 89 (11): 2041-2046 PMID28390158show ga Foot-and-mouth disease virus (FMDV) causes an economically important and highly contagious disease of cloven-hoofed animals such as cattle, swine, and sheep. FMD vaccine is the traditional way to protect against the disease, which can greatly reduce its occurrence. However, the use of FMD vaccines to protect early infection is limited. Therefore, the alternative strategy of applying antiviral agents is required to control the spread of FMDV in outbreak situations. As previously reported, LiCl has obviously inhibition effects on a variety of viruses such as transmissible gastroenteritis virus (TGEV), infectious bronchitis coronavirus (IBV), and pseudorabies herpesvirus and EV-A71 virus. In this study, our findings were the first to demonstrate that LiCl inhibition of the FMDV replication. In this study, BHK-21 cell was dose-dependent with LiCl at various stages of FMDV. Virus titration assay was calculated by the 50% tissue culture infected dose (TCID(50) ) with the Reed and Muench method. The cytotoxicity assay of LiCl was performed by the CCK8 kit. The expression level of viral mRNA was measured by RT-qPCR. The results revealed LiCl can inhibit FMDV replication, but it cannot affect FMDV attachment stage and entry stage in the course of FMDV life cycle. Further studies confirmed that the LiCl affect the replication stage of FMDV, especially the early stages of FMDV replication. So LiCl has potential as an effective anti-FMDV drug. Therefore, LiCl may be an effective drug for the control of FMDV. Based on that, the mechanism of the antiviral effect of LiCl on FMDV infection is need to in-depth research in vivo. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Cattle[MESH] |Cell Line[MESH] |DNA Replication/drug effects[MESH] |Foot-and-Mouth Disease Virus/*drug effects/genetics/physiology[MESH] |Foot-and-Mouth Disease/drug therapy/virology[MESH] |Lithium Chloride/*pharmacology[MESH] |Polymerase Chain Reaction[MESH] |RNA, Viral/genetics[MESH] |Sheep[MESH] |Swine[MESH] |Time Factors[MESH]Lithium chloride inhibits early stages of foot-and-mouth disease virus(epmc).pdf DeepDyve Pubget Overpricing