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10.1152/physiolgenomics.00017.2017 http://scihub22266oqcxt.onion/10.1152/physiolgenomics.00017.2017 28389525!5451551!28389525     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28389525&cmd=llinks): Failed to open stream: HTTP request failed! 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Role of renal transporters and novel regulatory interactions in the TAL that control blood pressure |pdf=|usr=}}{{28389525}} gab.com Text Role of renal transporters and novel regulatory interactions in the TAL that control blood pressure JO: Physiol Genomics http://www.kidney.de/pget.php?&tw=1&pmid=28389525 #FOAvip Hypertension (HTN), a major public health issue is currently the leading factor in the global burden of disease, where associated complications account for 9.4 million deaths worldwide every year. Excessive dietary salt intake is among the environmental factors that contribute to HTN, known as salt sensitivity. The heterogeneity of salt sensitivity and the multiple mechanisms that link high salt intake to increases in blood pressure are of upmost importance for therapeutic application. A continual increase in the kidney's reabsorption of sodium (Na(+)) relies on sequential actions at various segments along the nephron. When the distal segments of the nephron fail to regulate Na(+), the effects on Na(+) homeostasis are unfavorable. We propose that the specific nephron region where increased active uptake occurs as a result of variations in Na(+) reabsorption is at the thick ascending limb of the loop of Henle (TAL). The purpose of this review is to urge the consideration of the TAL as contributing to the pathophysiology of salt-sensitive HTN. Further research in this area will enable development of a therapeutic application for targeted treatment. Twit Text FOAVip Role of renal transporters and novel regulatory interactions in the TAL that control blood pressure ????Physiol Genomics http://www.kidney.de/pget.php?&tw=1&pmid=28389525 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28389525 #FOAvip English Wikipedia <ref>{{Cite pmid|28389525}}</ref> Role of renal transporters and novel regulatory interactions in the TAL that control blood pressure #MMPMID28389525 Graham LA; Dominiczak AF; Ferreri NR Physiol Genomics 2017[May]; 49 (5): 261-276 PMID28389525show ga Hypertension (HTN), a major public health issue is currently the leading factor in the global burden of disease, where associated complications account for 9.4 million deaths worldwide every year. Excessive dietary salt intake is among the environmental factors that contribute to HTN, known as salt sensitivity. The heterogeneity of salt sensitivity and the multiple mechanisms that link high salt intake to increases in blood pressure are of upmost importance for therapeutic application. A continual increase in the kidney's reabsorption of sodium (Na(+)) relies on sequential actions at various segments along the nephron. When the distal segments of the nephron fail to regulate Na(+), the effects on Na(+) homeostasis are unfavorable. We propose that the specific nephron region where increased active uptake occurs as a result of variations in Na(+) reabsorption is at the thick ascending limb of the loop of Henle (TAL). The purpose of this review is to urge the consideration of the TAL as contributing to the pathophysiology of salt-sensitive HTN. Further research in this area will enable development of a therapeutic application for targeted treatment. |Animals[MESH] |Anion Transport Proteins/genetics/*metabolism[MESH] |Biological Transport[MESH] |Blood Pressure/*physiology[MESH] |Cation Transport Proteins/genetics/*metabolism[MESH] |Humans[MESH] |Hypertension/*physiopathology[MESH] |Loop of Henle/anatomy & histology/*physiology/physiopathology[MESH] |Sodium-Hydrogen Exchanger 3/metabolism[MESH] |Solute Carrier Family 12, Member 1/metabolism[MESH]Role of renal transporters and novel regulatory interactions in the TA(epmc).pdf DeepDyve Pubget Overpricing