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10.1097/ALN.0000000000001601 http://scihub22266oqcxt.onion/10.1097/ALN.0000000000001601 28306698!ä!28306698 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Anesthesiology 2017 ; 126 (6): 1151-1168 Nephropedia Template TP {{tp|p=28306698|t=2017. Oral Application of Magnesium-L-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-alpha/Nuclear Factor-kappaB Signaling |pdf=|usr=}}{{28306698}} gab.com Text Oral Application of Magnesium-L-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-alpha/Nuclear Factor-kappaB Signaling JO: Anesthesiology http://www.kidney.de/pget.php?&tw=1&pmid=28306698 #FOAvip BACKGROUND: Antineoplastic agents, including vincristine, often induce neuropathic pain and magnesium deficiency clinically, but the causal link between them has not been determined. No drug is available for treating this form of neuropathic pain. METHODS: Injection of vincristine (0.1 mg . kg . day, intraperitoneally, for 10 days) was used to induce nociceptive sensitization, which was accessed with von Frey hairs and the plantar tester in adult male Sprague-Dawley rats. Magnesium-L- threonate was administered through drinking water (604 mg . kg . day). Extracellular and intracellular free Mg were measured by Calmagite chromometry and flow cytometry. Molecular biologic and electrophysiologic experiments were performed to expose the underlying mechanisms. RESULTS: Vincristine injection induced allodynia and hyperalgesia (n = 12), activated tumor necrosis factor-alpha/nuclear factor-kappaB signaling, and reduced free Mg in cerebrospinal fluid by 21.7 +/- 6.3% (mean +/- SD; n = 13) and in dorsal root ganglion neurons by 27 +/- 6% (n = 11). Reducing Mg activated tumor necrosis factor-alpha/nuclear factor-kappaB signaling in cultured dorsal root ganglion neurons. Oral application of magnesium-L-threonate prevented magnesium deficiency and attenuated both activation of tumor necrosis factor-alpha/nuclear factor-kappaB signaling and nociceptive sensitization (n = 12). Mechanistically, vincristine induced long-term potentiation at C-fiber synapses, up-regulated N-methyl-D-aspartate receptor type 2B subunit of N-methyl-D-aspartate receptor, and led to peptidergic C-fiber sprouting in spinal dorsal horn (n = 6 each). The vincristine-induced pathologic plasticity was blocked by intrathecal injection of nuclear factor-kappaB inhibitor (n = 6), mimicked by tumor necrosis factor-alpha, and substantially prevented by oral magnesium-L-threonate (n = 5). CONCLUSIONS: Vincristine may activate tumor necrosis factor-alpha/nuclear factor-kappaB pathway by reduction of intracellular magnesium, leading to spinal pathologic plasticity and nociceptive sensitization. Oral magnesium-L-threonate that prevents the magnesium deficiency is a novel approach to prevent neuropathic pain induced by chemotherapy. Twit Text FOAVip Oral Application of Magnesium-L-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-alpha/Nuclear Factor-kappaB Signaling ????Anesthesiology http://www.kidney.de/pget.php?&tw=1&pmid=28306698 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28306698 #FOAvip English Wikipedia <ref>{{Cite pmid|28306698}}</ref> Oral Application of Magnesium-L-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-alpha/Nuclear Factor-kappaB Signaling #MMPMID28306698 Xu T; Li D; Zhou X; Ouyang HD; Zhou LJ; Zhou H; Zhang HM; Wei XH; Liu G; Liu XG Anesthesiology 2017[Jun]; 126 (6): 1151-1168 PMID28306698show ga BACKGROUND: Antineoplastic agents, including vincristine, often induce neuropathic pain and magnesium deficiency clinically, but the causal link between them has not been determined. No drug is available for treating this form of neuropathic pain. METHODS: Injection of vincristine (0.1 mg . kg . day, intraperitoneally, for 10 days) was used to induce nociceptive sensitization, which was accessed with von Frey hairs and the plantar tester in adult male Sprague-Dawley rats. Magnesium-L- threonate was administered through drinking water (604 mg . kg . day). Extracellular and intracellular free Mg were measured by Calmagite chromometry and flow cytometry. Molecular biologic and electrophysiologic experiments were performed to expose the underlying mechanisms. RESULTS: Vincristine injection induced allodynia and hyperalgesia (n = 12), activated tumor necrosis factor-alpha/nuclear factor-kappaB signaling, and reduced free Mg in cerebrospinal fluid by 21.7 +/- 6.3% (mean +/- SD; n = 13) and in dorsal root ganglion neurons by 27 +/- 6% (n = 11). Reducing Mg activated tumor necrosis factor-alpha/nuclear factor-kappaB signaling in cultured dorsal root ganglion neurons. Oral application of magnesium-L-threonate prevented magnesium deficiency and attenuated both activation of tumor necrosis factor-alpha/nuclear factor-kappaB signaling and nociceptive sensitization (n = 12). Mechanistically, vincristine induced long-term potentiation at C-fiber synapses, up-regulated N-methyl-D-aspartate receptor type 2B subunit of N-methyl-D-aspartate receptor, and led to peptidergic C-fiber sprouting in spinal dorsal horn (n = 6 each). The vincristine-induced pathologic plasticity was blocked by intrathecal injection of nuclear factor-kappaB inhibitor (n = 6), mimicked by tumor necrosis factor-alpha, and substantially prevented by oral magnesium-L-threonate (n = 5). CONCLUSIONS: Vincristine may activate tumor necrosis factor-alpha/nuclear factor-kappaB pathway by reduction of intracellular magnesium, leading to spinal pathologic plasticity and nociceptive sensitization. Oral magnesium-L-threonate that prevents the magnesium deficiency is a novel approach to prevent neuropathic pain induced by chemotherapy. |Administration, Oral[MESH] |Animals[MESH] |Antineoplastic Agents, Phytogenic[MESH] |Butyrates/administration & dosage/*pharmacology[MESH] |Disease Models, Animal[MESH] |Hyperalgesia/chemically induced/*drug therapy[MESH] |Male[MESH] |NF-kappa B/*drug effects[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Signal Transduction/*drug effects[MESH] |Tumor Necrosis Factor-alpha/*drug effects[MESH]Oral Application of Magnesium-L-Threonate Attenuates Vincristine-induc(epmc).pdf DeepDyve Pubget Overpricing