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10.1172/JCI113399 http://scihub22266oqcxt.onion/10.1172/JCI113399 2830316!442541!2830316     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 1988 ; 81 (3): 885-92 Nephropedia Template TP {{tp|p=2830316|t=1988. Modulation of Na-K-ATPase activity in the mouse medullary thick ascending limb of Henle Effects of mineralocorticoids and sodium |pdf=|usr=}}{{2830316}} gab.com Text Modulation of Na-K-ATPase activity in the mouse medullary thick ascending limb of Henle Effects of mineralocorticoids and sodium JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=2830316 #FOAvip This study investigates the effect of variations in mineralocorticoid as well as cell sodium delivery and uptake on Na-K-ATPase activity in the mouse medullary thick ascending limb of Henle (mTALH). Pharmacologic doses of the mineralocorticoid deoxycorticosterone acetate (DOCA) resulted in a 28% increase of Na-K-ATPase activity. Furosemide-induced inhibition of sodium uptake by the mTALH cell also resulted in Na-K-ATPase activity reduction (45%). Sodium deprivation did not cause a clear change in enzyme activity, either at 3 d or 2 wk, likely reflecting the result of the opposing influences of decreased sodium delivery and increased endogenous aldosterone. Finally, the behavior of Na-K-ATPase activity at 3 d of sodium deprivation in the mTALH contrasted with a 60% increase in activity observed in the cortical collecting tubule, a nephron segment known to be responsive to mineralocorticoid, and this heterogeneity of response may suggest an important role for the mTALH in maintaining salt homeostasis. Twit Text FOAVip Modulation of Na-K-ATPase activity in the mouse medullary thick ascending limb of Henle Effects of mineralocorticoids and sodium ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=2830316 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2830316 #FOAvip English Wikipedia <ref>{{Cite pmid|2830316}}</ref> Modulation of Na-K-ATPase activity in the mouse medullary thick ascending limb of Henle Effects of mineralocorticoids and sodium #MMPMID2830316 Grossman EB; Hebert SC J Clin Invest 1988[Mar]; 81 (3): 885-92 PMID2830316show ga This study investigates the effect of variations in mineralocorticoid as well as cell sodium delivery and uptake on Na-K-ATPase activity in the mouse medullary thick ascending limb of Henle (mTALH). Pharmacologic doses of the mineralocorticoid deoxycorticosterone acetate (DOCA) resulted in a 28% increase of Na-K-ATPase activity. Furosemide-induced inhibition of sodium uptake by the mTALH cell also resulted in Na-K-ATPase activity reduction (45%). Sodium deprivation did not cause a clear change in enzyme activity, either at 3 d or 2 wk, likely reflecting the result of the opposing influences of decreased sodium delivery and increased endogenous aldosterone. Finally, the behavior of Na-K-ATPase activity at 3 d of sodium deprivation in the mTALH contrasted with a 60% increase in activity observed in the cortical collecting tubule, a nephron segment known to be responsive to mineralocorticoid, and this heterogeneity of response may suggest an important role for the mTALH in maintaining salt homeostasis. |Aldosterone/blood[MESH] |Animals[MESH] |Ca(2+) Mg(2+)-ATPase/metabolism[MESH] |Desoxycorticosterone/administration & dosage/*pharmacology[MESH] |Diet, Sodium-Restricted[MESH] |Furosemide/administration & dosage[MESH] |Kidney Tubules, Collecting/enzymology/metabolism[MESH] |Kidney Tubules/*enzymology[MESH] |Loop of Henle/drug effects/*enzymology/metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred Strains[MESH] |Sodium-Potassium-Exchanging ATPase/*metabolism[MESH] |Sodium/administration & dosage/*pharmacology[MESH]Modulation of Na-K-ATPase activity in the mouse medullary thick ascend(epmc).pdf DeepDyve Pubget Overpricing