Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.celrep.2017.02.026 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.02.026 28273457!ä!28273457 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2017 ; 18 (10): 2427-2440 Nephropedia Template TP {{tp|p=28273457|t=2017. Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node |pdf=|usr=}}{{28273457}} gab.com Text Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28273457 #FOAvip The mechanism by which inflammation influences the adaptive response to vaccines is not fully understood. Here, we examine the role of lymph node macrophages (LNMs) in the induction of the cytokine storm triggered by inactivated influenza virus vaccine. Following vaccination, LNMs undergo inflammasome-independent necrosis-like death that is reliant on MyD88 and Toll-like receptor 7 (TLR7) expression and releases pre-stored interleukin-1alpha (IL-1alpha). Furthermore, activated medullary macrophages produce interferon-beta (IFN-beta) that induces the autocrine secretion of IL-1alpha. We also found that macrophage depletion promotes lymph node-resident dendritic cell (LNDC) relocation and affects the capacity of CD11b(+) LNDCs to capture virus and express co-stimulatory molecules. Inhibition of the IL-1alpha-induced inflammatory cascade reduced B cell responses, while co-administration of recombinant IL-1alpha increased the humoral response. Stimulation of the IL-1alpha inflammatory pathway might therefore represent a strategy to enhance antigen presentation by LNDCs and improve the humoral response against influenza vaccines. Twit Text FOAVip Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28273457 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28273457 #FOAvip English Wikipedia <ref>{{Cite pmid|28273457}}</ref> Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node #MMPMID28273457 Chatziandreou N; Farsakoglu Y; Palomino-Segura M; D'Antuono R; Pizzagalli DU; Sallusto F; Lukacs-Kornek V; Uguccioni M; Corti D; Turley SJ; Lanzavecchia A; Carroll MC; Gonzalez SF Cell Rep 2017[Mar]; 18 (10): 2427-2440 PMID28273457show ga The mechanism by which inflammation influences the adaptive response to vaccines is not fully understood. Here, we examine the role of lymph node macrophages (LNMs) in the induction of the cytokine storm triggered by inactivated influenza virus vaccine. Following vaccination, LNMs undergo inflammasome-independent necrosis-like death that is reliant on MyD88 and Toll-like receptor 7 (TLR7) expression and releases pre-stored interleukin-1alpha (IL-1alpha). Furthermore, activated medullary macrophages produce interferon-beta (IFN-beta) that induces the autocrine secretion of IL-1alpha. We also found that macrophage depletion promotes lymph node-resident dendritic cell (LNDC) relocation and affects the capacity of CD11b(+) LNDCs to capture virus and express co-stimulatory molecules. Inhibition of the IL-1alpha-induced inflammatory cascade reduced B cell responses, while co-administration of recombinant IL-1alpha increased the humoral response. Stimulation of the IL-1alpha inflammatory pathway might therefore represent a strategy to enhance antigen presentation by LNDCs and improve the humoral response against influenza vaccines. |*Vaccination[MESH] |Animals[MESH] |Antigen Presentation/immunology[MESH] |Cell Death[MESH] |Cell Movement[MESH] |Dendritic Cells/*immunology[MESH] |Immunity, Humoral[MESH] |Inflammation/*pathology[MESH] |Influenza Vaccines/administration & dosage/*immunology[MESH] |Interferon-beta/metabolism[MESH] |Interleukin-1alpha/metabolism[MESH] |Lymph Nodes/*immunology[MESH] |Macrophage Activation[MESH] |Macrophages/*pathology/*virology[MESH] |Mice, Inbred C57BL[MESH] |Myeloid Differentiation Factor 88/metabolism[MESH] |Orthomyxoviridae Infections/*immunology/virology[MESH] |Toll-Like Receptor 7/metabolism[MESH]Macrophage Death following Influenza Vaccination Initiates the Inflamm(epmc).pdf DeepDyve Pubget Overpricing