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10.1155/2017/1456473

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suck abstract from ncbi


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pmid28243595      Biomed+Res+Int 2017 ; 2017 (ä): 1456473
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  • CNS Metastases from Bone and Soft Tissue Sarcomas in Children, Adolescents, and Young Adults: Are They Really So Rare? #MMPMID28243595
  • Bekiesinska-Figatowska M; Duczkowska A; Duczkowski M; Bragoszewska H; Romaniuk-Doroszewska A; Iwanowska B; Szkudlinska-Pawlak S; Madzik J; Bilska K; Raciborska A
  • Biomed Res Int 2017[]; 2017 (ä): 1456473 PMID28243595show ga
  • Purpose. To check whether primary involvement of brain/spinal cord by bone/soft tissue sarcomas' metastases in children is as rare as described and to present various morphological forms of bone/soft tissue sarcomas' CNS metastases. Methods. Patients with first diagnosis in 1999-2014 treated at single center were included with whole course of disease evaluation. Brain/spinal canal magnetic resonance imaging (MRI)/computed tomography were performed in cases suspicious for CNS metastases. Extension from skull/vertebral column metastases was excluded. Results. 550 patients were included. MRI revealed CNS metastases in 19 patients (incidence 3.45%), 14 boys, aged 5-22 years. There were 12/250 osteosarcoma cases, 2/200 Ewing's sarcoma, 1/50 chondrosarcoma, 3/49 rhabdomyosarcoma (RMS), and 1/1 malignant mesenchymoma. There were 10 single metastases and 7 cases of multiple ones; in 2 RMS cases only leptomeningeal spread in brain and spinal cord was found. Calcified metastases were found in 3 patients and hemorrhagic in 4. In one RMS patient there were numerous solid, cystic, hemorrhagic lesions and leptomeningeal spread. Conclusions. CNS metastases are rare and late in children with bone/soft tissue sarcomas, although in our material more frequent (3.45%) than in other reports (0.7%). Hematogenous spread to brain and hemorrhagic and calcified lesions dominated in osteosarcoma. Ewing sarcoma tended to metastasize to skull bones. Soft tissue sarcomas presented various morphological forms.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Bone Neoplasms/*pathology[MESH]
  • |Central Nervous System Neoplasms/*secondary[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Kaplan-Meier Estimate[MESH]
  • |Male[MESH]
  • |Soft Tissue Neoplasms/*pathology[MESH]


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