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10.1021/acsami.7b00813 http://scihub22266oqcxt.onion/10.1021/acsami.7b00813 28240546!ä!28240546 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Appl+Mater+Interfaces 2017 ; 9 (11): 9506-9515 Nephropedia Template TP {{tp|p=28240546|t=2017. High-Purity Magnesium Staples Suppress Inflammatory Response in Rectal Anastomoses |pdf=|usr=}}{{28240546}} gab.com Text High-Purity Magnesium Staples Suppress Inflammatory Response in Rectal Anastomoses JO: ACS Appl Mater Interfaces http://www.kidney.de/pget.php?&tw=1&pmid=28240546 #FOAvip Magnesium-based materials are promising biodegradable implants, although the impact of magnesium on rectal anastomotic inflammation is poorly understood. Thus, we investigated the inflammatory effects of high-purity Mg staples in rectal anastomoses by in vivo luciferase reporter gene expression in transgenic mice, hematoxylin-eosin staining, immunohistochemistry, and Western blotting. As expected, strong IL-1beta-mediated inflammation and inflammatory cell infiltration were observed 1 day after rectal anastomoses were stapled with high-purity Mg or Ti. However, inflammation and inflammatory cell infiltration decreased more robustly 4-7 days postoperation in tissues stapled with high-purity Mg. This rapid reduction in inflammation was confirmed by immunohistochemical analysis of IL-6 and TNF-alpha. Western blot also suggested that the reduced inflammatory response is due to suppressed TLR4/NF-kappaB signaling. In contrast, MCP-1, uPAR, and VEGF were abundantly expressed, in line with the notion that expression of these proteins is regulated by feedback between the VEGF and NF-kappaB pathways. In vitro expression of MCP-1, uPAR, and VEGF was also similarly high in primary rectal mucosal epithelial cells exposed to extracts from Mg staples, as measured by antibody array. Collectively, the results suggest that high-purity Mg staples suppress the inflammatory response during rectal anastomoses via TLR4/NF-kappaB and VEGF signaling. Twit Text FOAVip High-Purity Magnesium Staples Suppress Inflammatory Response in Rectal Anastomoses ????ACS Appl Mater Interfaces http://www.kidney.de/pget.php?&tw=1&pmid=28240546 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28240546 #FOAvip English Wikipedia <ref>{{Cite pmid|28240546}}</ref> High-Purity Magnesium Staples Suppress Inflammatory Response in Rectal Anastomoses #MMPMID28240546 Xia J; Chen H; Yan J; Wu H; Wang H; Guo J; Zhang X; Zhang S; Zhao C; Chen Y ACS Appl Mater Interfaces 2017[Mar]; 9 (11): 9506-9515 PMID28240546show ga Magnesium-based materials are promising biodegradable implants, although the impact of magnesium on rectal anastomotic inflammation is poorly understood. Thus, we investigated the inflammatory effects of high-purity Mg staples in rectal anastomoses by in vivo luciferase reporter gene expression in transgenic mice, hematoxylin-eosin staining, immunohistochemistry, and Western blotting. As expected, strong IL-1beta-mediated inflammation and inflammatory cell infiltration were observed 1 day after rectal anastomoses were stapled with high-purity Mg or Ti. However, inflammation and inflammatory cell infiltration decreased more robustly 4-7 days postoperation in tissues stapled with high-purity Mg. This rapid reduction in inflammation was confirmed by immunohistochemical analysis of IL-6 and TNF-alpha. Western blot also suggested that the reduced inflammatory response is due to suppressed TLR4/NF-kappaB signaling. In contrast, MCP-1, uPAR, and VEGF were abundantly expressed, in line with the notion that expression of these proteins is regulated by feedback between the VEGF and NF-kappaB pathways. In vitro expression of MCP-1, uPAR, and VEGF was also similarly high in primary rectal mucosal epithelial cells exposed to extracts from Mg staples, as measured by antibody array. Collectively, the results suggest that high-purity Mg staples suppress the inflammatory response during rectal anastomoses via TLR4/NF-kappaB and VEGF signaling. |Anastomosis, Surgical[MESH] |Animals[MESH] |Cytokines[MESH] |Inflammation[MESH] |Magnesium/*chemistry[MESH] |Mice[MESH] |NF-kappa B[MESH] |Rectal Diseases[MESH]High-Purity Magnesium Staples Suppress Inflammatory Response in Rectal(epmc).pdf DeepDyve Pubget Overpricing