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10.1021/acsinfecdis.6b00206 http://scihub22266oqcxt.onion/10.1021/acsinfecdis.6b00206 28215073/?report=reader!5509442!28215073     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Infect+Dis 2017 ; 3 (5): 349-359 Nephropedia Template TP {{tp|p=28215073|t=2017. Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile |pdf=|usr=}}{{28215073}} gab.com Text Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile JO: ACS Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=28215073 #FOAvip In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options currently exist, many of which result in disease relapse. We sought to identify molecules specifically targeting C. difficile in high-throughput screens of our diversity-oriented synthesis compound collection. We identified two scaffolds with apparently novel mechanisms of action that selectively target C. difficile while having little to no activity against other intestinal anaerobes; preliminary evidence suggests that compounds from one of these scaffolds target the glutamate racemase. In vivo efficacy data suggest that both compound series may provide lead optimization candidates. Twit Text FOAVip Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile ????ACS Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=28215073 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28215073 #FOAvip English Wikipedia <ref>{{Cite pmid|28215073}}</ref> Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile #MMPMID28215073 Duvall JR; Bedard L; Naylor-Olsen AM; Manson AL; Bittker JA; Sun W; Fitzgerald ME; He Z; Lee MD 4th; Marie JC; Muncipinto G; Rush D; Xu D; Xu H; Zhang M; Earl AM; Palmer MA; Foley MA; Vacca JP; Scherer CA ACS Infect Dis 2017[May]; 3 (5): 349-359 PMID28215073show ga In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options currently exist, many of which result in disease relapse. We sought to identify molecules specifically targeting C. difficile in high-throughput screens of our diversity-oriented synthesis compound collection. We identified two scaffolds with apparently novel mechanisms of action that selectively target C. difficile while having little to no activity against other intestinal anaerobes; preliminary evidence suggests that compounds from one of these scaffolds target the glutamate racemase. In vivo efficacy data suggest that both compound series may provide lead optimization candidates. |Amino Acid Isomerases/*antagonists & inhibitors/genetics/metabolism[MESH] |Animals[MESH] |Anti-Bacterial Agents/chemical synthesis/*pharmacology[MESH] |Bacterial Proteins/*antagonists & inhibitors/genetics/metabolism[MESH] |Clostridioides difficile/*drug effects/enzymology/genetics/growth & development[MESH] |Drug Design[MESH] |Enterocolitis, Pseudomembranous/*drug therapy/microbiology/mortality/pathology[MESH] |Female[MESH] |Gene Expression[MESH] |Gram-Negative Bacteria/drug effects/growth & development[MESH] |Gram-Positive Bacteria/drug effects/growth & development[MESH] |Heterocyclic Compounds, 2-Ring/chemical synthesis/*pharmacology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Microbial Sensitivity Tests[MESH] |Phenylurea Compounds/chemical synthesis/*pharmacology[MESH] |Pyrroles/chemical synthesis/*pharmacology[MESH] |Quinolines/chemical synthesis/*pharmacology[MESH] |Species Specificity[MESH] |Structure-Activity Relationship[MESH]Identification of Highly Specific Diversity-Oriented Synthesis-Derived(epmc).pdf DeepDyve Pubget Overpricing