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10.1111/dmcn.13394 http://scihub22266oqcxt.onion/10.1111/dmcn.13394 28160302!ä!28160302 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Med+Child+Neurol 2017 ; 59 (5): 544-549 Nephropedia Template TP {{tp|p=28160302|t=2017. Autism spectrum disorder and other neurobehavioural comorbidities in rare disorders of the Ras/MAPK pathway |pdf=|usr=}}{{28160302}} gab.com Text Autism spectrum disorder and other neurobehavioural comorbidities in rare disorders of the Ras/MAPK pathway JO: Dev Med Child Neurol http://www.kidney.de/pget.php?&tw=1&pmid=28160302 #FOAvip AIM: To investigate the cognitive and behavioural phenotype in rare disorders of the Ras/MAPK pathway, namely Noonan, cardiofaciocutaneous (CFC), and Costello syndromes, particularly prevalence of autism spectrum disorder (ASD) and attention-deficit-hyperactivity disorder (ADHD). METHOD: Fifty children were recruited over 10 months through the regional genetics service and advertisements. A range of parent, child, and observational measures were administered including Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Scale. RESULTS: Using the Collaborative Programme for Excellence in Autism criteria, 12 out of 40 children with Noonan syndrome (30%) showed ASD, and 12 out of 40 (30%) with partial ASD features and 16 out of 40 (40%) showed non-ASD. The Noonan syndrome ASD group showed male dominance in a ratio of 5:1. In the CFC group, eight out of nine children met the criteria for ASD, with equal sex distribution. Additionally 19 out of 40 (48%) of the Noonan syndrome group and eight out of nine (88.9%) of the CFC group scored met clinical criteria for ADHD. Only one child was in the Costello syndrome group. INTERPRETATION: This is the first systematic study to suggest a high prevalence of ASD in Noonan and CFC syndromes, and thus offers crucial evidence to support the importance of the Ras/MAPK pathway in the aetiology of ASD. Limitations include the inevitable possibility of a sampling bias in a rare disorder study of this kind. Twit Text FOAVip Autism spectrum disorder and other neurobehavioural comorbidities in rare disorders of the Ras/MAPK pathway ????Dev Med Child Neurol http://www.kidney.de/pget.php?&tw=1&pmid=28160302 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28160302 #FOAvip English Wikipedia <ref>{{Cite pmid|28160302}}</ref> Autism spectrum disorder and other neurobehavioural comorbidities in rare disorders of the Ras/MAPK pathway #MMPMID28160302 Garg S; Brooks A; Burns A; Burkitt-Wright E; Kerr B; Huson S; Emsley R; Green J Dev Med Child Neurol 2017[May]; 59 (5): 544-549 PMID28160302show ga AIM: To investigate the cognitive and behavioural phenotype in rare disorders of the Ras/MAPK pathway, namely Noonan, cardiofaciocutaneous (CFC), and Costello syndromes, particularly prevalence of autism spectrum disorder (ASD) and attention-deficit-hyperactivity disorder (ADHD). METHOD: Fifty children were recruited over 10 months through the regional genetics service and advertisements. A range of parent, child, and observational measures were administered including Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Scale. RESULTS: Using the Collaborative Programme for Excellence in Autism criteria, 12 out of 40 children with Noonan syndrome (30%) showed ASD, and 12 out of 40 (30%) with partial ASD features and 16 out of 40 (40%) showed non-ASD. The Noonan syndrome ASD group showed male dominance in a ratio of 5:1. In the CFC group, eight out of nine children met the criteria for ASD, with equal sex distribution. Additionally 19 out of 40 (48%) of the Noonan syndrome group and eight out of nine (88.9%) of the CFC group scored met clinical criteria for ADHD. Only one child was in the Costello syndrome group. INTERPRETATION: This is the first systematic study to suggest a high prevalence of ASD in Noonan and CFC syndromes, and thus offers crucial evidence to support the importance of the Ras/MAPK pathway in the aetiology of ASD. Limitations include the inevitable possibility of a sampling bias in a rare disorder study of this kind. |Adolescent[MESH] |Attention Deficit Disorder with Hyperactivity/*epidemiology[MESH] |Autism Spectrum Disorder/complications/*epidemiology[MESH] |Child[MESH] |Comorbidity[MESH] |Ectodermal Dysplasia/complications/genetics[MESH] |Executive Function/physiology[MESH] |Facies[MESH] |Failure to Thrive/complications/genetics[MESH] |Female[MESH] |Heart Defects, Congenital/complications/genetics[MESH] |Humans[MESH] |Intelligence Tests[MESH] |Male[MESH] |Mitogen-Activated Protein Kinase Kinases/genetics[MESH] |Noonan Syndrome/*epidemiology/genetics[MESH] |Psychiatric Status Rating Scales[MESH] |Retrospective Studies[MESH] |Severity of Illness Index[MESH] |Temporomandibular Joint Dysfunction Syndrome/complications/epidemiology/genetics[MESH]Autism spectrum disorder and other neurobehavioural comorbidities in r(epmc).pdf DeepDyve Pubget Overpricing