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10.1111/add.13765 http://scihub22266oqcxt.onion/10.1111/add.13765 28107598/?report=reader!5984202!28107598     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Addiction 2017 ; 112 (6): 1077-1085 Nephropedia Template TP {{tp|p=28107598|t=2017. Dropout in clinical trials of pharmacological treatment for methamphetamine dependence: the role of initial abstinence |pdf=|usr=}}{{28107598}} gab.com Text Dropout in clinical trials of pharmacological treatment for methamphetamine dependence: the role of initial abstinence JO: Addiction http://www.kidney.de/pget.php?&tw=1&pmid=28107598 #FOAvip BACKGROUND AND AIMS: High rates of loss to follow-up represent a significant challenge to clinical trials of pharmacological treatments for methamphetamine (MA) use disorder. We aimed to estimate and test the relationship between achieving and maintaining abstinence in the initial weeks of study participation and subsequent retention in such trials, hypothesizing that participants able to achieve early abstinence would be less likely to drop out. DESIGN: Data from four randomized controlled trials (RCTs) of pharmacological treatments for MA use disorder were pooled and analyzed using a random-effects approach. SETTING: All trials were conducted in the greater Los Angeles, CA, USA area. PARTICIPANTS: A total of 440 participants were included; trials were conducted between 2004 and 2014. MEASUREMENTS: Participants' ability to achieve a brief period of initial abstinence was measured as the number of MA-negative urine screens completed in the first 2 weeks of the trials. Outcomes were the likelihood of dropout, i.e. missing two consecutive weeks of scheduled urine drug screens, and the number of days participants were retained in the trials. FINDINGS: Study participants achieved an average of three (of six possible) negative urine screens during the first 2 weeks of the trials, 51% dropped out and the average number of days retained was 60 (of 90 maximum). Each additional negative urine screen achieved during the first 2 weeks of the study reduced multiplicatively the odds of dropout by 41% [odds ratio (OR) = 0.59, 95% confidence interval (CI) = 0.53, 0.66]. Abstinence was also a significant predictor of retention time; the hazard ratio for non-completion was 0.75 per additional negative urine screen (95% CI = 0.71, 0.80). CONCLUSIONS: Participants in randomized controlled trials of pharmacological treatments for methamphetamine use disorder who are able to achieve a brief period of early abstinence are retained longer in the trials and are less likely to drop out overall. Twit Text FOAVip Dropout in clinical trials of pharmacological treatment for methamphetamine dependence: the role of initial abstinence ????Addiction http://www.kidney.de/pget.php?&tw=1&pmid=28107598 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28107598 #FOAvip English Wikipedia <ref>{{Cite pmid|28107598}}</ref> Dropout in clinical trials of pharmacological treatment for methamphetamine dependence: the role of initial abstinence #MMPMID28107598 Cook R; Quinn B; Heinzerling K; Shoptaw S Addiction 2017[Jun]; 112 (6): 1077-1085 PMID28107598show ga BACKGROUND AND AIMS: High rates of loss to follow-up represent a significant challenge to clinical trials of pharmacological treatments for methamphetamine (MA) use disorder. We aimed to estimate and test the relationship between achieving and maintaining abstinence in the initial weeks of study participation and subsequent retention in such trials, hypothesizing that participants able to achieve early abstinence would be less likely to drop out. DESIGN: Data from four randomized controlled trials (RCTs) of pharmacological treatments for MA use disorder were pooled and analyzed using a random-effects approach. SETTING: All trials were conducted in the greater Los Angeles, CA, USA area. PARTICIPANTS: A total of 440 participants were included; trials were conducted between 2004 and 2014. MEASUREMENTS: Participants' ability to achieve a brief period of initial abstinence was measured as the number of MA-negative urine screens completed in the first 2 weeks of the trials. Outcomes were the likelihood of dropout, i.e. missing two consecutive weeks of scheduled urine drug screens, and the number of days participants were retained in the trials. FINDINGS: Study participants achieved an average of three (of six possible) negative urine screens during the first 2 weeks of the trials, 51% dropped out and the average number of days retained was 60 (of 90 maximum). Each additional negative urine screen achieved during the first 2 weeks of the study reduced multiplicatively the odds of dropout by 41% [odds ratio (OR) = 0.59, 95% confidence interval (CI) = 0.53, 0.66]. Abstinence was also a significant predictor of retention time; the hazard ratio for non-completion was 0.75 per additional negative urine screen (95% CI = 0.71, 0.80). CONCLUSIONS: Participants in randomized controlled trials of pharmacological treatments for methamphetamine use disorder who are able to achieve a brief period of early abstinence are retained longer in the trials and are less likely to drop out overall. |*Lost to Follow-Up[MESH] |Adult[MESH] |Amphetamine-Related Disorders/*drug therapy[MESH] |Female[MESH] |Humans[MESH] |Los Angeles[MESH] |Male[MESH] |Methamphetamine[MESH] |Patient Dropouts/*statistics & numerical data[MESH]Dropout in clinical trials of pharmacological treatment for methamphet(epmc).pdf DeepDyve Pubget Overpricing