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10.1016/j.ijcard.2017.01.011 http://scihub22266oqcxt.onion/10.1016/j.ijcard.2017.01.011 28100427!ä!28100427 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Cardiol 2017 ; 232 (ä): 243-246 Nephropedia Template TP {{tp|p=28100427|t=2017. The possible role of propofol in drug-induced torsades de pointes: A real-world single-center analysis |pdf=|usr=}}{{28100427}} gab.com Text The possible role of propofol in drug-induced torsades de pointes: A real-world single-center analysis JO: Int J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=28100427 #FOAvip BACKGROUND: Torsades de pointes (TdP) is a polymorphic ventricular tachycardia associated with QT prolongation. Propofol is a sedative-anesthetic with proarrhythmic effects on cardiac myocytes. We performed a retrospective study to determine the incidence of TdP following propofol exposure at Mayo Clinic (Rochester, MN) from 08/11/1998-11/20/2015. METHODS: We queried our database using key search terms to identify patients exposed to propofol who developed TdP perioperatively or during non-surgical sedation. QT intervals were obtained from electrocardiograms (ECGs) performed before propofol exposure and after documented TdP and were corrected using Fridericia and Framingham methods. T wave peak-to-end (Tp-e)/QT ratios were also calculated. RESULTS: A total of 628,784 patients received propofol over 17.3years. Of these patients, 21 developed TdP (12, postoperatively; 3, intraoperatively; 6, during sedation). There were 17 patients who were exposed to at least one factor associated with QT-prolongation, including QT-prolonging medications in 8 patients, heart rate <60 beats per minute in 8 patients, potassium <3.5mmol/L in 4 patients, magnesium <1.8mg/dL in 2 patients, and subarachnoid hemorrhage in 2 patients. The number of patients with QTc>500ms using Fridericia correction was significantly higher from baseline following exposure to propofol (1 patient vs 6 patients, P=0.04); however no significant difference was observed with Framingham correction. CONCLUSION: In our study, TdP after propofol administration occurred with an annual incidence of 1.93 per million and was often associated with other risk factors. Nevertheless, propofol should be administered with caution in patients at risk of developing TdP. Twit Text FOAVip The possible role of propofol in drug-induced torsades de pointes: A real-world single-center analysis ????Int J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=28100427 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28100427 #FOAvip English Wikipedia <ref>{{Cite pmid|28100427}}</ref> The possible role of propofol in drug-induced torsades de pointes: A real-world single-center analysis #MMPMID28100427 Abrich VA; Ramakrishna H; Mehta A; Mookadam F; Srivathsan K Int J Cardiol 2017[Apr]; 232 (ä): 243-246 PMID28100427show ga BACKGROUND: Torsades de pointes (TdP) is a polymorphic ventricular tachycardia associated with QT prolongation. Propofol is a sedative-anesthetic with proarrhythmic effects on cardiac myocytes. We performed a retrospective study to determine the incidence of TdP following propofol exposure at Mayo Clinic (Rochester, MN) from 08/11/1998-11/20/2015. METHODS: We queried our database using key search terms to identify patients exposed to propofol who developed TdP perioperatively or during non-surgical sedation. QT intervals were obtained from electrocardiograms (ECGs) performed before propofol exposure and after documented TdP and were corrected using Fridericia and Framingham methods. T wave peak-to-end (Tp-e)/QT ratios were also calculated. RESULTS: A total of 628,784 patients received propofol over 17.3years. Of these patients, 21 developed TdP (12, postoperatively; 3, intraoperatively; 6, during sedation). There were 17 patients who were exposed to at least one factor associated with QT-prolongation, including QT-prolonging medications in 8 patients, heart rate <60 beats per minute in 8 patients, potassium <3.5mmol/L in 4 patients, magnesium <1.8mg/dL in 2 patients, and subarachnoid hemorrhage in 2 patients. The number of patients with QTc>500ms using Fridericia correction was significantly higher from baseline following exposure to propofol (1 patient vs 6 patients, P=0.04); however no significant difference was observed with Framingham correction. CONCLUSION: In our study, TdP after propofol administration occurred with an annual incidence of 1.93 per million and was often associated with other risk factors. Nevertheless, propofol should be administered with caution in patients at risk of developing TdP. |*Forecasting[MESH] |Aged[MESH] |Electrocardiography/drug effects[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Heart Conduction System/drug effects/*physiopathology[MESH] |Heart Rate/*drug effects[MESH] |Humans[MESH] |Hypnotics and Sedatives/administration & dosage[MESH] |Male[MESH] |Middle Aged[MESH] |Propofol/*administration & dosage[MESH] |Retrospective Studies[MESH] |Torsades de Pointes/chemically induced/*drug therapy/physiopathology[MESH]The possible role of propofol in drug-induced torsades de pointes: A r(epmc).pdf DeepDyve Pubget Overpricing