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10.1111/febs.14001 http://scihub22266oqcxt.onion/10.1111/febs.14001 28052575!7164106!28052575     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+J 2017 ; 284 (10): 1518-1539 Nephropedia Template TP {{tp|p=28052575|t=2017. Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases |pdf=|usr=}}{{28052575}} gab.com Text Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases JO: FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=28052575 #FOAvip Proteases are enzymes that hydrolyze the peptide bond of peptide substrates and proteins. Despite significant progress in recent years, one of the greatest challenges in the design and testing of substrates, inhibitors and activity-based probes for proteolytic enzymes is achieving specificity toward only one enzyme. This specificity is particularly important if the enzyme is present with other enzymes with a similar catalytic mechanism and substrate specificity but completely different functionality. The cross-reactivity of substrates, inhibitors and activity-based probes with other enzymes can significantly impair or even prevent investigations of a target protease. In this review, we describe important concepts and the latest challenges, focusing mainly on peptide-based substrate specificity techniques used to distinguish individual enzymes within major protease families. Twit Text FOAVip Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases ????FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=28052575 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28052575 #FOAvip English Wikipedia <ref>{{Cite pmid|28052575}}</ref> Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases #MMPMID28052575 Kasperkiewicz P; Poreba M; Groborz K; Drag M FEBS J 2017[May]; 284 (10): 1518-1539 PMID28052575show ga Proteases are enzymes that hydrolyze the peptide bond of peptide substrates and proteins. Despite significant progress in recent years, one of the greatest challenges in the design and testing of substrates, inhibitors and activity-based probes for proteolytic enzymes is achieving specificity toward only one enzyme. This specificity is particularly important if the enzyme is present with other enzymes with a similar catalytic mechanism and substrate specificity but completely different functionality. The cross-reactivity of substrates, inhibitors and activity-based probes with other enzymes can significantly impair or even prevent investigations of a target protease. In this review, we describe important concepts and the latest challenges, focusing mainly on peptide-based substrate specificity techniques used to distinguish individual enzymes within major protease families. |Animals[MESH] |Endopeptidases/metabolism[MESH] |Humans[MESH] |Peptide Hydrolases/*metabolism[MESH] |Protease Inhibitors/pharmacology[MESH]Emerging challenges in the design of selective substrates, inhibitors (epmc).pdf DeepDyve Pubget Overpricing