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10.1016/j.celrep.2016.11.062 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.11.062 28009291!?!28009291 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28009291&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cell+Rep 2016 ; 17 (12): 3219-3232 Nephropedia Template TP {{tp|p=28009291|t=2016. Myeloid-Derived Suppressor Cells Are Controlled by Regulatory T Cells via TGF-beta during Murine Colitis |pdf=|usr=}}{{28009291}} gab.com Text Myeloid-Derived Suppressor Cells Are Controlled by Regulatory T Cells via TGF-beta during Murine Colitis JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28009291 #FOAvip Myeloid-derived suppressor cells (MDSCs) are well known regulators of regulatory T cells (Treg cells); however, the direct regulation of MDSCs by Treg cells has not been well characterized. We find that colitis caused by functional deficiency of Treg cells leads to altered expansion and reduced function of MDSCs. During differentiation of MDSCs in vitro from bone marrow cells, Treg cells enhanced MDSC function and controlled their differentiation through a mechanism involving transforming growth factor-beta (TGF-beta). TGF-beta-deficient Treg cells were not able to regulate MDSC function in an experimentally induced model of colitis. Finally, we evaluated the therapeutic effect of TGF-beta-mediated in-vitro-differentiated MDSCs on colitis. Adoptive transfer of MDSCs that differentiated with TGF-beta led to better colitis prevention than the transfer of MDSCs that differentiated without TGF-beta. Our results demonstrate an interaction between Treg cells and MDSCs that contributes to the regulation of MDSC proliferation and the acquisition of immunosuppressive functions. Twit Text FOAVip Myeloid-Derived Suppressor Cells Are Controlled by Regulatory T Cells via TGF-beta during Murine Colitis ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28009291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28009291 #FOAvip English Wikipedia <ref>{{Cite pmid|28009291}}</ref> Myeloid-Derived Suppressor Cells Are Controlled by Regulatory T Cells via TGF-beta during Murine Colitis #MMPMID28009291 Lee CR; Kwak Y; Yang T; Han JH; Park SH; Ye MB; Lee W; Sim KY; Kang JA; Kim YC; Mazmanian SK; Park SG Cell Rep 2016[Dec]; 17 (12): 3219-3232 PMID28009291show ga Myeloid-derived suppressor cells (MDSCs) are well known regulators of regulatory T cells (Treg cells); however, the direct regulation of MDSCs by Treg cells has not been well characterized. We find that colitis caused by functional deficiency of Treg cells leads to altered expansion and reduced function of MDSCs. During differentiation of MDSCs in vitro from bone marrow cells, Treg cells enhanced MDSC function and controlled their differentiation through a mechanism involving transforming growth factor-beta (TGF-beta). TGF-beta-deficient Treg cells were not able to regulate MDSC function in an experimentally induced model of colitis. Finally, we evaluated the therapeutic effect of TGF-beta-mediated in-vitro-differentiated MDSCs on colitis. Adoptive transfer of MDSCs that differentiated with TGF-beta led to better colitis prevention than the transfer of MDSCs that differentiated without TGF-beta. Our results demonstrate an interaction between Treg cells and MDSCs that contributes to the regulation of MDSC proliferation and the acquisition of immunosuppressive functions. |Adoptive Transfer[MESH] |Animals[MESH] |Bone Marrow Cells/cytology[MESH] |Cell Differentiation/genetics[MESH] |Cell Proliferation/genetics[MESH] |Colitis/chemically induced/*genetics/metabolism[MESH] |Dextran Sulfate/toxicity[MESH] |Humans[MESH] |Inflammation/*genetics/metabolism[MESH] |Mice[MESH] |Myeloid-Derived Suppressor Cells/*cytology/metabolism[MESH] |T-Lymphocytes, Regulatory/*cytology/metabolism[MESH]Myeloid-Derived Suppressor Cells Are Controlled by Regulatory T Cells (epmc).pdf DeepDyve Pubget Overpricing