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10.1016/j.biopha.2016.12.033 http://scihub22266oqcxt.onion/10.1016/j.biopha.2016.12.033 27978497!ä!27978497 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Pharmacother 2017 ; 86 (ä): 177-184 Nephropedia Template TP {{tp|p=27978497|t=2017. Magnesium Isoglycyrrhizinate attenuates lipopolysaccharide-induced depressive-like behavior in mice |pdf=|usr=}}{{27978497}} gab.com Text Magnesium Isoglycyrrhizinate attenuates lipopolysaccharide-induced depressive-like behavior in mice JO: Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=27978497 #FOAvip Magnesium Isoglycyrrhizinate (MI) is a magnesium salt of 18alpha-GA stereoisomer which has been reported to exert hepatoprotective activity. The aim of the present study was to ascertain the underlying mechanisms behind the action of Magnesium Isoglycyrrhizinate on neuroinflammatation and oxidative stress in LPS-stimulated mice. Mice were pretreated with Magnesium Isoglycyrrhizinate (MI, 25, 50mg/kg) as well as fluoxetine (Flu, positive control, 20mg/kg) once daily for one week before intraperitoneal injection of LPS (0.83mg/kg). Pretreatments with MI and Flu significantly improved immobility time in tail suspension test (TST) and forced swim test (FST) as well as locomotor activity in open-field test (OFT). In addition, the levels of pro-inflammatory cytokines and oxidative stress in serum and hippocampus were also suppressed effectively by MI and Flu administrations. Western blot analysis showed the up-regulated levels of p-Jak3, p-STAT3, p-NF-kappaBp65, and p-IkappaBalpha in mice exposed to LPS, while different degrees of down-regulation in these expression were observed in MI (25, 50mg/kg) and Flu (20mg/kg) groups respectively. Taken together, our obtained results demonstrated that Magnesium Isoglycyrrhizinate (MI) exhibited an antidepressant-like effect in LPS-induced mice, which might be mediated by JAK/STAT/NF-kappaB signaling pathway. Twit Text FOAVip Magnesium Isoglycyrrhizinate attenuates lipopolysaccharide-induced depressive-like behavior in mice ????Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=27978497 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27978497 #FOAvip English Wikipedia <ref>{{Cite pmid|27978497}}</ref> Magnesium Isoglycyrrhizinate attenuates lipopolysaccharide-induced depressive-like behavior in mice #MMPMID27978497 Jiang W; Chen Q; Li P; Lu Q; Pei X; Sun Y; Wang G; Hao K Biomed Pharmacother 2017[Feb]; 86 (ä): 177-184 PMID27978497show ga Magnesium Isoglycyrrhizinate (MI) is a magnesium salt of 18alpha-GA stereoisomer which has been reported to exert hepatoprotective activity. The aim of the present study was to ascertain the underlying mechanisms behind the action of Magnesium Isoglycyrrhizinate on neuroinflammatation and oxidative stress in LPS-stimulated mice. Mice were pretreated with Magnesium Isoglycyrrhizinate (MI, 25, 50mg/kg) as well as fluoxetine (Flu, positive control, 20mg/kg) once daily for one week before intraperitoneal injection of LPS (0.83mg/kg). Pretreatments with MI and Flu significantly improved immobility time in tail suspension test (TST) and forced swim test (FST) as well as locomotor activity in open-field test (OFT). In addition, the levels of pro-inflammatory cytokines and oxidative stress in serum and hippocampus were also suppressed effectively by MI and Flu administrations. Western blot analysis showed the up-regulated levels of p-Jak3, p-STAT3, p-NF-kappaBp65, and p-IkappaBalpha in mice exposed to LPS, while different degrees of down-regulation in these expression were observed in MI (25, 50mg/kg) and Flu (20mg/kg) groups respectively. Taken together, our obtained results demonstrated that Magnesium Isoglycyrrhizinate (MI) exhibited an antidepressant-like effect in LPS-induced mice, which might be mediated by JAK/STAT/NF-kappaB signaling pathway. |Animals[MESH] |Antidepressive Agents/pharmacology/*therapeutic use[MESH] |Depression/*chemically induced/*drug therapy/metabolism[MESH] |Dose-Response Relationship, Drug[MESH] |Drugs, Chinese Herbal/pharmacology/*therapeutic use[MESH] |Lipopolysaccharides/*toxicity[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred ICR[MESH] |Motor Activity/drug effects/physiology[MESH] |Random Allocation[MESH] |Saponins/pharmacology/*therapeutic use[MESH]Magnesium Isoglycyrrhizinate attenuates lipopolysaccharide-induced de(epmc).pdf DeepDyve Pubget Overpricing