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10.1002/eji.201646686 http://scihub22266oqcxt.onion/10.1002/eji.201646686 27925643!7163530!27925643     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27925643&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2017 ; 47 (2): 364-373 Nephropedia Template TP {{tp|p=27925643|t=2017. Primary and secondary hemophagocytic lymphohistiocytosis have different patterns of T-cell activation, differentiation and repertoire |pdf=|usr=}}{{27925643}} gab.com Text Primary and secondary hemophagocytic lymphohistiocytosis have different patterns of T-cell activation, differentiation and repertoire JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27925643 #FOAvip Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening inflammatory syndrome characterized by hyperactivation of lymphocytes and histiocytes. T cells play a key role in HLH pathogenesis, but their differentiation pattern is not well characterized in patients with active HLH. We compared T-cell activation patterns between patients with familial HLH (1 degrees HLH), 2 degrees HLH without apparent infectious trigger (2 degrees HLH) and 2 degrees HLH induced by a viral infection (2 degrees V-HLH). Polyclonal CD8(+) T cells are highly activated in 1 degrees HLH and 2 degrees V-HLH, but less in 2 degrees HLH as assessed by HLA-DR expression and marker combination with CD45RA, CCR7, CD127, PD-1 and CD57. Absence of increased HLA-DR expression on T cells excluded active 1 degrees HLH with high sensitivity and specificity. A high proportion of polyclonal CD127(-) CD4(+) T cells expressing HLA-DR, CD57, and perforin is a signature of infants with 1 degrees HLH, much less prominent in virus-associated 2 degrees HLH. The similar pattern and extent of CD8(+) T-cell activation compared to 2 degrees V-HLH is compatible with a viral trigger of 1 degrees HLH. However, in most 1 degrees HLH patients no triggering infection was documented and the unique activation of cytotoxic CD4(+) T cells indicates that the overall T-cell response in 1 degrees HLH is different. This may reflect different pathways of pathogenesis of these two HLH variants. Twit Text FOAVip Primary and secondary hemophagocytic lymphohistiocytosis have different patterns of T-cell activation, differentiation and repertoire ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27925643 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27925643 #FOAvip English Wikipedia <ref>{{Cite pmid|27925643}}</ref> Primary and secondary hemophagocytic lymphohistiocytosis have different patterns of T-cell activation, differentiation and repertoire #MMPMID27925643 Ammann S; Lehmberg K; Zur Stadt U; Janka G; Rensing-Ehl A; Klemann C; Heeg M; Bode S; Fuchs I; Ehl S Eur J Immunol 2017[Feb]; 47 (2): 364-373 PMID27925643show ga Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening inflammatory syndrome characterized by hyperactivation of lymphocytes and histiocytes. T cells play a key role in HLH pathogenesis, but their differentiation pattern is not well characterized in patients with active HLH. We compared T-cell activation patterns between patients with familial HLH (1 degrees HLH), 2 degrees HLH without apparent infectious trigger (2 degrees HLH) and 2 degrees HLH induced by a viral infection (2 degrees V-HLH). Polyclonal CD8(+) T cells are highly activated in 1 degrees HLH and 2 degrees V-HLH, but less in 2 degrees HLH as assessed by HLA-DR expression and marker combination with CD45RA, CCR7, CD127, PD-1 and CD57. Absence of increased HLA-DR expression on T cells excluded active 1 degrees HLH with high sensitivity and specificity. A high proportion of polyclonal CD127(-) CD4(+) T cells expressing HLA-DR, CD57, and perforin is a signature of infants with 1 degrees HLH, much less prominent in virus-associated 2 degrees HLH. The similar pattern and extent of CD8(+) T-cell activation compared to 2 degrees V-HLH is compatible with a viral trigger of 1 degrees HLH. However, in most 1 degrees HLH patients no triggering infection was documented and the unique activation of cytotoxic CD4(+) T cells indicates that the overall T-cell response in 1 degrees HLH is different. This may reflect different pathways of pathogenesis of these two HLH variants. |CD57 Antigens/metabolism[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |Cell Differentiation[MESH] |Cells, Cultured[MESH] |Female[MESH] |HLA-DR Antigens/metabolism[MESH] |Humans[MESH] |Infant[MESH] |Infant, Newborn[MESH] |Lymphocyte Activation[MESH] |Lymphohistiocytosis, Hemophagocytic/diagnosis/etiology/*immunology[MESH] |Male[MESH] |Perforin/metabolism[MESH] |Receptors, Antigen, T-Cell/genetics[MESH]Primary and secondary hemophagocytic lymphohistiocytosis have differen(epmc).pdf DeepDyve Pubget Overpricing