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10.1007/s00228-016-2165-3 http://scihub22266oqcxt.onion/10.1007/s00228-016-2165-3 27909740!ä!27909740 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Clin+Pharmacol 2017 ; 73 (3): 325-331 Nephropedia Template TP {{tp|p=27909740|t=2017. Clinical pharmacokinetics of magnesium sulfate in the treatment of children with severe acute asthma |pdf=|usr=}}{{27909740}} gab.com Text Clinical pharmacokinetics of magnesium sulfate in the treatment of children with severe acute asthma JO: Eur J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27909740 #FOAvip PURPOSE: Intravenous (IV) magnesium sulfate (MgSO(4)) is used as adjunct therapy to treat acute asthma exacerbations. Despite its clinical use, there is a limited understanding of the disposition of magnesium in children. METHODS: To explore the pharmacokinetics (PK) of IV MgSO(4) in this population, we collected retrospective data from 54 children who received IV MgSO(4) for treatment of an acute asthma exacerbation at Primary Children's Hospital in Salt Lake City, UT. These data were analyzed using population PK modeling techniques in NONMEM(R) to determine sources of variability affecting the disposition of magnesium, as well as to predict the dose of IV MgSO(4) needed to achieve clinical benefit. RESULTS: The covariate analysis found that only weight was a significant predictor of magnesium concentrations in children. Estimated model parameters suggested that magnesium exhibits a short serum half-life (2.7 h) in children. The average endogenous magnesium concentration (prior to administration of IV MgSO(4)) was estimated to be 21 mg/L. Simulated data suggested that doses between 50 and 75 mg/kg are required to achieve concentration-time profiles within a hypothesized target therapeutic range between 25 and 40 mg/L. CONCLUSIONS: These results provide new insight into the disposition of IV MgSO(4) in children and provide dosing guidelines for future prospective studies of IV MgSO(4) in children with acute asthma. Twit Text FOAVip Clinical pharmacokinetics of magnesium sulfate in the treatment of children with severe acute asthma ????Eur J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27909740 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27909740 #FOAvip English Wikipedia <ref>{{Cite pmid|27909740}}</ref> Clinical pharmacokinetics of magnesium sulfate in the treatment of children with severe acute asthma #MMPMID27909740 Rower JE; Liu X; Yu T; Mundorff M; Sherwin CM; Johnson MD Eur J Clin Pharmacol 2017[Mar]; 73 (3): 325-331 PMID27909740show ga PURPOSE: Intravenous (IV) magnesium sulfate (MgSO(4)) is used as adjunct therapy to treat acute asthma exacerbations. Despite its clinical use, there is a limited understanding of the disposition of magnesium in children. METHODS: To explore the pharmacokinetics (PK) of IV MgSO(4) in this population, we collected retrospective data from 54 children who received IV MgSO(4) for treatment of an acute asthma exacerbation at Primary Children's Hospital in Salt Lake City, UT. These data were analyzed using population PK modeling techniques in NONMEM(R) to determine sources of variability affecting the disposition of magnesium, as well as to predict the dose of IV MgSO(4) needed to achieve clinical benefit. RESULTS: The covariate analysis found that only weight was a significant predictor of magnesium concentrations in children. Estimated model parameters suggested that magnesium exhibits a short serum half-life (2.7 h) in children. The average endogenous magnesium concentration (prior to administration of IV MgSO(4)) was estimated to be 21 mg/L. Simulated data suggested that doses between 50 and 75 mg/kg are required to achieve concentration-time profiles within a hypothesized target therapeutic range between 25 and 40 mg/L. CONCLUSIONS: These results provide new insight into the disposition of IV MgSO(4) in children and provide dosing guidelines for future prospective studies of IV MgSO(4) in children with acute asthma. |Acute Disease[MESH] |Adolescent[MESH] |Asthma/*drug therapy[MESH] |Child[MESH] |Child, Preschool[MESH] |Female[MESH] |Humans[MESH] |Magnesium Sulfate/*pharmacokinetics/therapeutic use[MESH] |Male[MESH]Clinical pharmacokinetics of magnesium sulfate in the treatment of chi(epmc).pdf DeepDyve Pubget Overpricing