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10.1159/000234949

http://scihub22266oqcxt.onion/10.1159/000234949
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2788143!ä!2788143

suck abstract from ncbi


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pmid2788143      Int+Arch+Allergy+Appl+Immunol 1989 ; 89 (2-3): 217-21
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  • Effect of magnesium deficiency on interleukin production by Fisher rats: effect of interleukins on reduced in vitro lymphocyte responses to concanavalin A and lipopolysaccharide #MMPMID2788143
  • Yiangou M; Hadjipetrou-Kourounakis L
  • Int Arch Allergy Appl Immunol 1989[]; 89 (2-3): 217-21 PMID2788143show ga
  • The ability of rats fed a magnesium-deficient diet to produce interleukins (ILs) and the effect of ILs on in vitro lymphocyte mitogenesis have been studied in rats. Lack of magnesium resulted in a lower number of plastic-adherent spleen cells and in a reduction of IL-1 production. IL-2 production was not significantly affected, indicating differential sensitivity of T cells to magnesium deficiency. The diminished mitogenic response of splenocytes to concanavalin A (Con-A) was restored by the addition of IL-1 supernatant, while the addition of IL-2 supernatant and recombinant IL-2 resulted in significantly greater enhancement of proliferation in response to Con-A, compared with that of control spleen cells. The fact that recombinant IL-2 restored the T-cell responses to Con-A indicates that the active factor in the IL-2 supernatant is IL-2.
  • |*Lymphocyte Activation[MESH]
  • |Animals[MESH]
  • |Concanavalin A/pharmacology[MESH]
  • |Interleukin-1/*biosynthesis[MESH]
  • |Interleukin-2/*biosynthesis[MESH]
  • |Lipopolysaccharides/pharmacology[MESH]
  • |Macrophages/*metabolism[MESH]
  • |Magnesium Deficiency/*immunology[MESH]
  • |Rats[MESH]
  • |Rats, Inbred F344[MESH]
  • |Spleen/cytology[MESH]


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