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10.1016/j.antiviral.2016.11.003 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2016.11.003 27838352/?report=reader!5215849!27838352     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2017 ; 137 (ä): 14-22 Nephropedia Template TP {{tp|p=27838352|t=2017. Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model |pdf=|usr=}}{{27838352}} gab.com Text Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=27838352 #FOAvip Zika virus (ZIKV) is currently undergoing pandemic emergence. While disease is typically subclinical, severe neurologic manifestations in fetuses and newborns after congenital infection underscore an urgent need for antiviral interventions. The adenosine analog BCX4430 has broad-spectrum activity against a wide range of RNA viruses, including potent in vivo activity against yellow fever, Marburg and Ebola viruses. We tested this compound against African and Asian lineage ZIKV in cytopathic effect inhibition and virus yield reduction assays in various cell lines. To further evaluate the efficacy in a relevant animal model, we developed a mouse model of severe ZIKV infection, which recapitulates various human disease manifestations including peripheral virus replication, conjunctivitis, encephalitis and myelitis. Time-course quantification of viral RNA accumulation demonstrated robust viral replication in several relevant tissues, including high and persistent viral loads observed in the brain and testis. The presence of viral RNA in various tissues was confirmed by an infectious culture assay as well as immunohistochemical staining of tissue sections. Treatment of ZIKV-infected mice with BCX4430 significantly improved outcome even when treatment was initiated during the peak of viremia. The demonstration of potent activity of BCX4430 against ZIKV in a lethal mouse model warrant its continued clinical development. Twit Text FOAVip Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=27838352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27838352 #FOAvip English Wikipedia <ref>{{Cite pmid|27838352}}</ref> Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model #MMPMID27838352 Julander JG; Siddharthan V; Evans J; Taylor R; Tolbert K; Apuli C; Stewart J; Collins P; Gebre M; Neilson S; Van Wettere A; Lee YM; Sheridan WP; Morrey JD; Babu YS Antiviral Res 2017[Jan]; 137 (ä): 14-22 PMID27838352show ga Zika virus (ZIKV) is currently undergoing pandemic emergence. While disease is typically subclinical, severe neurologic manifestations in fetuses and newborns after congenital infection underscore an urgent need for antiviral interventions. The adenosine analog BCX4430 has broad-spectrum activity against a wide range of RNA viruses, including potent in vivo activity against yellow fever, Marburg and Ebola viruses. We tested this compound against African and Asian lineage ZIKV in cytopathic effect inhibition and virus yield reduction assays in various cell lines. To further evaluate the efficacy in a relevant animal model, we developed a mouse model of severe ZIKV infection, which recapitulates various human disease manifestations including peripheral virus replication, conjunctivitis, encephalitis and myelitis. Time-course quantification of viral RNA accumulation demonstrated robust viral replication in several relevant tissues, including high and persistent viral loads observed in the brain and testis. The presence of viral RNA in various tissues was confirmed by an infectious culture assay as well as immunohistochemical staining of tissue sections. Treatment of ZIKV-infected mice with BCX4430 significantly improved outcome even when treatment was initiated during the peak of viremia. The demonstration of potent activity of BCX4430 against ZIKV in a lethal mouse model warrant its continued clinical development. |Adenine/analogs & derivatives[MESH] |Adenosine/analogs & derivatives[MESH] |Animals[MESH] |Antiviral Agents/administration & dosage/*pharmacology/*therapeutic use[MESH] |Brain/virology[MESH] |Cell Line[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Male[MESH] |Mice[MESH] |Purine Nucleosides/administration & dosage/*pharmacology/*therapeutic use[MESH] |Pyrrolidines[MESH] |RNA, Viral[MESH] |Testis/virology[MESH] |Viral Load/drug effects[MESH] |Viremia[MESH] |Virus Replication/drug effects[MESH] |Zika Virus Infection/*drug therapy/virology[MESH]Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika(epmc).pdf DeepDyve Pubget Overpricing