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10.1089/wound.2015.0682

http://scihub22266oqcxt.onion/10.1089/wound.2015.0682
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suck abstract from ncbi


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pmid27785377      Adv+Wound+Care+(New+Rochelle) 2016 ; 5 (10): 432-443
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  • Peroxy Pyruvic Acid-Containing Topical Anti-Infective: A Potential Candidate for a Wound Instillation Solution #MMPMID27785377
  • Neas ED; Dunn JA; Silva ED; Chambers AM; Luckasen GJ; Jaskowiak A
  • Adv Wound Care (New Rochelle) 2016[Oct]; 5 (10): 432-443 PMID27785377show ga
  • Objective: Evaluate the therapeutic properties of a peroxy pyruvic acid (PPA)-containing topical anti-infective in a human ex-vivo model that replicates the natural conditions of a human chronic wound. Approach: Wound material was extracted from patients with nonhealing diabetic ulcers, venous stasis ulcers, and arterial wounds. Microbial species were identified, and wound colonization was quantified. Extracted samples were then exposed to a PPA-containing topical anti-infective as an instillation solution with negative pressure wound therapy NPWT at concentrations of 1,000, 1,500, or 2,500 ppm for a period of 1, 5, or 10 min to determine the effect of exposure on isolated pathogens, including effect on proteins. Results: A total of 32 samples were collected from patients. Samples presented with a range of bacteria and fungi representing 14 genera and 22 species, many of which are or are evolving to be resistant to many, if not most, current systemic antibiotics. Thirteen of twenty-three samples (57%) from chronic wounds had bacteria counts >/=10(5) and most were 6 logs or more. Seven of 10 samples (70%) from acute wounds had bacteria counts
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