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10.1016/j.dci.2016.09.013 http://scihub22266oqcxt.onion/10.1016/j.dci.2016.09.013 27746172!7102680!27746172     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27746172&cmd=llinks): Failed to open stream: HTTP request failed! 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Macrophages from disease resistant B2 haplotype chickens activate T lymphocytes more effectively than macrophages from disease susceptible B19 birds |pdf=|usr=}}{{27746172}} gab.com Text Macrophages from disease resistant B2 haplotype chickens activate T lymphocytes more effectively than macrophages from disease susceptible B19 birds JO: Dev Comp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27746172 #FOAvip Resistance to respiratory pathogens, including coronavirus-induced infection and clinical illness in chickens has been correlated with the B (MHC) complex and differential ex vivo macrophage responses. In the current study, in vitro T lymphocyte activation measured by IFNgamma release was significantly higher in B2 versus B19 haplotypes. AIV infection of macrophages was required to activate T lymphocytes and prior in vivo exposure of chickens to NP AIV plasmid enhanced responses to infected macrophages. This study suggests that the demonstrated T lymphocyte activation is in part due to antigen presentation by the macrophages as well as cytokine release by the infected macrophages, with B2 haplotypes showing stronger activation. These responses were present both in CD4 and CD8 T lymphocytes. In contrast, T lymphocytes stimulated by ConA showed greater IFNgamma release of B19 haplotype cells, further indicating the greater responses in B2 haplotypes to infection is due to macrophages, but not T cells. In summary, resistance of B2 haplotype chickens appears to be directly linked to a more vigorous innate immune response and the role macrophages play in activating adaptive immunity. Twit Text FOAVip Macrophages from disease resistant B2 haplotype chickens activate T lymphocytes more effectively than macrophages from disease susceptible B19 birds ????Dev Comp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27746172 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27746172 #FOAvip English Wikipedia <ref>{{Cite pmid|27746172}}</ref> Macrophages from disease resistant B2 haplotype chickens activate T lymphocytes more effectively than macrophages from disease susceptible B19 birds #MMPMID27746172 Collisson E; Griggs L; Drechsler Y Dev Comp Immunol 2017[Feb]; 67 (ä): 249-256 PMID27746172show ga Resistance to respiratory pathogens, including coronavirus-induced infection and clinical illness in chickens has been correlated with the B (MHC) complex and differential ex vivo macrophage responses. In the current study, in vitro T lymphocyte activation measured by IFNgamma release was significantly higher in B2 versus B19 haplotypes. AIV infection of macrophages was required to activate T lymphocytes and prior in vivo exposure of chickens to NP AIV plasmid enhanced responses to infected macrophages. This study suggests that the demonstrated T lymphocyte activation is in part due to antigen presentation by the macrophages as well as cytokine release by the infected macrophages, with B2 haplotypes showing stronger activation. These responses were present both in CD4 and CD8 T lymphocytes. In contrast, T lymphocytes stimulated by ConA showed greater IFNgamma release of B19 haplotype cells, further indicating the greater responses in B2 haplotypes to infection is due to macrophages, but not T cells. In summary, resistance of B2 haplotype chickens appears to be directly linked to a more vigorous innate immune response and the role macrophages play in activating adaptive immunity. |*Immunity, Innate[MESH] |Adaptive Immunity[MESH] |Animals[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |Cells, Cultured[MESH] |Chickens/*immunology[MESH] |Disease Susceptibility[MESH] |Haplotypes[MESH] |Influenza in Birds/*immunology[MESH] |Lymphocyte Activation[MESH] |Macrophages/*immunology/virology[MESH] |Orthomyxoviridae/*immunology[MESH] |Paracrine Communication[MESH]Macrophages from disease resistant B2 haplotype chickens activate T ly(epmc).pdf DeepDyve Pubget Overpricing