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10.1177/1470320316672349 http://scihub22266oqcxt.onion/10.1177/1470320316672349 27733642!5843909!27733642     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Renin+Angiotensin+Aldosterone+Syst 2016 ; 17 (4): ä Nephropedia Template TP {{tp|p=27733642|t=2016. Mitochondrial-dependent mechanisms are involved in angiotensin II-induced apoptosis in dopaminergic neurons |pdf=|usr=}}{{27733642}} gab.com Text Mitochondrial-dependent mechanisms are involved in angiotensin II-induced apoptosis in dopaminergic neurons JO: J Renin Angiotensin Aldosterone Syst http://www.kidney.de/pget.php?&tw=1&pmid=27733642 #FOAvip INTRODUCTION: We recently demonstrated that angiotensin II (Ang II) was involved in the etiology of Parkinson's disease (PD) via induction of apoptosis of dopaminergic neurons, but the mechanisms are not completely elucidated. Here, we asked whether mitochondrial-dependent mechanisms contributed to the Ang II-induced dopaminergic neuronal apoptosis. MATERIALS AND METHODS: CATH.a cells were incubated with Ang II in combination with mitochondrial permeability transition pore (mPTP) inhibitors or angiotensin receptor antagonists, and apoptosis rate, caspase-3 activity, cytochrome c levels, and mPTP opening were assessed. RESULTS: We showed that Ang II triggered apoptosis via a mitochondrial-dependent pathway, as elevated cytochrome c levels were observed in the cytosol. By employing cyclosporin A and sanglifehrin A, two specific mPTP inhibitors, we revealed that cytochrome c release from mitochondria into cytoplasm was ascribed to mPTP opening. Meanwhile, the aforementioned effects could be abrogated by an AT(1) receptor antagonist losartan rather than an AT(2) receptor antagonist PD123319. CONCLUSION: This study demonstrates that Ang II triggers mitochondrial-dependent apoptosis via facilitating mPTP opening through an AT(1) receptor-mediated fashion in dopaminergic neurons. These findings give insight into the effect of Ang II in the etiology of PD, and reinforce the application of AT(1) receptor antagonists for PD treatment. Twit Text FOAVip Mitochondrial-dependent mechanisms are involved in angiotensin II-induced apoptosis in dopaminergic neurons ????J Renin Angiotensin Aldosterone Syst http://www.kidney.de/pget.php?&tw=1&pmid=27733642 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27733642 #FOAvip English Wikipedia <ref>{{Cite pmid|27733642}}</ref> Mitochondrial-dependent mechanisms are involved in angiotensin II-induced apoptosis in dopaminergic neurons #MMPMID27733642 Ou Z; Jiang T; Gao Q; Tian YY; Zhou JS; Wu L; Shi JQ; Zhang YD J Renin Angiotensin Aldosterone Syst 2016[Oct]; 17 (4): ä PMID27733642show ga INTRODUCTION: We recently demonstrated that angiotensin II (Ang II) was involved in the etiology of Parkinson's disease (PD) via induction of apoptosis of dopaminergic neurons, but the mechanisms are not completely elucidated. Here, we asked whether mitochondrial-dependent mechanisms contributed to the Ang II-induced dopaminergic neuronal apoptosis. MATERIALS AND METHODS: CATH.a cells were incubated with Ang II in combination with mitochondrial permeability transition pore (mPTP) inhibitors or angiotensin receptor antagonists, and apoptosis rate, caspase-3 activity, cytochrome c levels, and mPTP opening were assessed. RESULTS: We showed that Ang II triggered apoptosis via a mitochondrial-dependent pathway, as elevated cytochrome c levels were observed in the cytosol. By employing cyclosporin A and sanglifehrin A, two specific mPTP inhibitors, we revealed that cytochrome c release from mitochondria into cytoplasm was ascribed to mPTP opening. Meanwhile, the aforementioned effects could be abrogated by an AT(1) receptor antagonist losartan rather than an AT(2) receptor antagonist PD123319. CONCLUSION: This study demonstrates that Ang II triggers mitochondrial-dependent apoptosis via facilitating mPTP opening through an AT(1) receptor-mediated fashion in dopaminergic neurons. These findings give insight into the effect of Ang II in the etiology of PD, and reinforce the application of AT(1) receptor antagonists for PD treatment. |Angiotensin II/*pharmacology[MESH] |Animals[MESH] |Apoptosis/*drug effects[MESH] |Cell Line[MESH] |Dopaminergic Neurons/*cytology/drug effects/*metabolism[MESH] |Mice[MESH] |Mitochondria/drug effects/*metabolism[MESH] |Mitochondrial Membrane Transport Proteins/metabolism[MESH] |Mitochondrial Permeability Transition Pore[MESH] |Receptor, Angiotensin, Type 1/metabolism[MESH] |Receptor, Angiotensin, Type 2/metabolism[MESH]Mitochondrial-dependent mechanisms are involved in angiotensin II-indu(epmc).pdf DeepDyve Pubget Overpricing