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10.1039/c6bm00290k http://scihub22266oqcxt.onion/10.1039/c6bm00290k 27709132!ä!27709132 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomater+Sci 2016 ; 4 (11): 1574-1583 Nephropedia Template TP {{tp|p=27709132|t=2016. Improved osteogenesis and angiogenesis of magnesium-doped calcium phosphate cement via macrophage immunomodulation |pdf=|usr=}}{{27709132}} gab.com Text Improved osteogenesis and angiogenesis of magnesium-doped calcium phosphate cement via macrophage immunomodulation JO: Biomater Sci http://www.kidney.de/pget.php?&tw=1&pmid=27709132 #FOAvip Immune responses are vital for bone regeneration and play an essential role in the fate of biomaterials after implantation. As a kind of plastic cell, macrophages are central regulators of the immune response during the infection and wound healing process including osteogenesis and angiogenesis. Magnesium-calcium phosphate cement (MCPC) has been reported as a promising candidate for bone repair with promoted osteogenesis both in vitro and in vivo. However, relatively little is known about the effects of MCPC on immune response and the following outcome. In this study, we investigated the interactions between macrophages and MCPC. Here we found that the pro-inflammatory cytokines including TNF-alpha and IL-6 were less expressed and the bone repair related cytokine of TGF-beta1 was up-regulated by macrophages in MCPC extract. Furthermore, the enhanced osteogenic capacity of BMSCs and angiogenic potential of HUVECs were acquired in vitro by the MCPC-induced immune microenvironment. These findings suggest that MCPC is able to facilitate bone healing by endowing favorable osteoimmunomodulatory properties and influencing crosstalk behavior between immune cells and osteogenesis-related cells. Twit Text FOAVip Improved osteogenesis and angiogenesis of magnesium-doped calcium phosphate cement via macrophage immunomodulation ????Biomater Sci http://www.kidney.de/pget.php?&tw=1&pmid=27709132 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27709132 #FOAvip English Wikipedia <ref>{{Cite pmid|27709132}}</ref> Improved osteogenesis and angiogenesis of magnesium-doped calcium phosphate cement via macrophage immunomodulation #MMPMID27709132 Wang M; Yu Y; Dai K; Ma Z; Liu Y; Wang J; Liu C Biomater Sci 2016[Oct]; 4 (11): 1574-1583 PMID27709132show ga Immune responses are vital for bone regeneration and play an essential role in the fate of biomaterials after implantation. As a kind of plastic cell, macrophages are central regulators of the immune response during the infection and wound healing process including osteogenesis and angiogenesis. Magnesium-calcium phosphate cement (MCPC) has been reported as a promising candidate for bone repair with promoted osteogenesis both in vitro and in vivo. However, relatively little is known about the effects of MCPC on immune response and the following outcome. In this study, we investigated the interactions between macrophages and MCPC. Here we found that the pro-inflammatory cytokines including TNF-alpha and IL-6 were less expressed and the bone repair related cytokine of TGF-beta1 was up-regulated by macrophages in MCPC extract. Furthermore, the enhanced osteogenic capacity of BMSCs and angiogenic potential of HUVECs were acquired in vitro by the MCPC-induced immune microenvironment. These findings suggest that MCPC is able to facilitate bone healing by endowing favorable osteoimmunomodulatory properties and influencing crosstalk behavior between immune cells and osteogenesis-related cells. |*Neovascularization, Physiologic[MESH] |*Osteogenesis[MESH] |Bone Cements/*chemistry[MESH] |Calcium Phosphates/chemistry/immunology[MESH] |Humans[MESH] |Immunomodulation[MESH] |Macrophages/*immunology[MESH]Improved osteogenesis and angiogenesis of magnesium-doped calcium phos(epmc).pdf DeepDyve Pubget Overpricing