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10.1007/s00266-016-0703-0

http://scihub22266oqcxt.onion/10.1007/s00266-016-0703-0
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suck abstract from ncbi


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pmid27699461      Aesthetic+Plast+Surg 2016 ; 40 (6): 901-907
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  • The Use of Integra Dermal Regeneration Template Versus Flaps for Reconstruction of Full-Thickness Scalp Defects Involving the Calvaria: A Cost-Benefit Analysis #MMPMID27699461
  • Schiavon M; Francescon M; Drigo D; Salloum G; Baraziol R; Tesei J; Fraccalanza E; Barbone F
  • Aesthetic Plast Surg 2016[Dec]; 40 (6): 901-907 PMID27699461show ga
  • BACKGROUND: INTEGRA((R)) Dermal Regeneration Template is a well-known and widely used acellular dermal matrix. Although it helps to solve many challenging problems in reconstructive surgery, the product cost may make it an expensive alternative compared to other reconstruction procedures. This retrospective study aims at comparing INTEGRA-based treatment to flap surgery in terms of cost and benefit. PATIENTS AND METHODS: We considered only patients treated for scalp defects with bone exposure in order to obtain two groups as homogeneous as possible. We identified two groups of patients: 17 patients treated with INTEGRA and 18 patients treated with flaps. All patients were admitted in our institution between 2004 and 2010, and presented a defect of the scalp following trauma or surgery for cancer, causing a loss of the soft tissues of the scalp with bone exposure without pericranium. To calculate the cost in constant euros of each treatment, three parameters were evaluated for each patient: cost of the surgical procedure (number of doctors and nurses involved, surgery duration, anesthesia, material used for surgery), hospitalization cost (hospitalization duration, dressings, drugs, topical agents), and outpatient cost (number of dressing changes, personnel cost, dressings type, anti-infective agents). The statistical test used in this study was the Wilcoxon Mann-Whitney (alpha = 0.05). RESULTS: No significant difference was characterized between the two groups for gender, age, presence of diabetes, mean defect size, and number of surgical procedures. All patients healed with good quality and durable closure. The median total cost per patient was euro11,121 (interquartile range (IQR) 8327-15,571) for the INTEGRA group and euro7259 (IQR 1852-24,443) for the flap group (p = 0.34). A subgroup of patients (six patients in the INTEGRA group and five patients in the flap group) showing defects larger than 100 cm(2) were considered in a second analysis. Median total cost was euro11,825 (IQR 10,695-15,751) for the INTEGRA group and euro23,244 (IQR 17,348-26,942) for the flap group. CONCLUSION: Both treatments led to a good healing of the lesions with formation of soft and resistant tissue. No significant difference was characterized between the two groups for days of hospitalization and costs. In cases of patients with defects larger than 100 cm(2) for whom major surgery is needed, the treatment with INTEGRA seemed to be less expensive than the treatment with free flaps or pedicle flaps. LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the A5 online Instructions to Authors. www.springer.com/00266 .
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Chondroitin Sulfates/*economics[MESH]
  • |Cohort Studies[MESH]
  • |Collagen/*economics[MESH]
  • |Cost-Benefit Analysis[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Free Tissue Flaps/*economics/*transplantation[MESH]
  • |Hospital Costs[MESH]
  • |Humans[MESH]
  • |Injury Severity Score[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Plastic Surgery Procedures/adverse effects/*methods[MESH]
  • |Postoperative Complications/physiopathology/surgery[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Assessment[MESH]
  • |Scalp/injuries/*surgery[MESH]
  • |Skin Transplantation/economics/*methods[MESH]
  • |Skull/injuries/surgery[MESH]
  • |Treatment Outcome[MESH]


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