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10.1007/s13277-016-5317-2 http://scihub22266oqcxt.onion/10.1007/s13277-016-5317-2 27629139!ä!27629139 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Tumour+Biol 2016 ; 37 (11): 14721-14731 Nephropedia Template TP {{tp|p=27629139|t=2016. TRPM7 channel inhibition mediates midazolam-induced proliferation loss in human malignant glioma |pdf=|usr=}}{{27629139}} gab.com Text TRPM7 channel inhibition mediates midazolam-induced proliferation loss in human malignant glioma JO: Tumour Biol http://www.kidney.de/pget.php?&tw=1&pmid=27629139 #FOAvip The melastatin-like transient receptor potential 7 (TRPM7) has been implicated in proliferation or apoptosis of some cancers, indicating the potential of TRPM7 as an anti-anaplastic target. Here, we identified the characteristic TRPM7 channel currents in human malignant glioma MGR2 cells, which could be blocked by a pharmacologic inhibitor Gd(3+). We mined the clinical sample data from Oncomine Database and found that human malignant glioma tissues expressed higher TRPM7 mRNA than normal brain ones. Importantly, we identified a widely used clinical anesthetic midazolam as a TRPM7 inhibitor. Midazolam treatment for seconds suppressed the TRPM7 currents and calcium influx, and treatment for 48 h inhibited the TRPM7 expression. The inhibitory effect on TRPM7 accounts for the proliferation loss and G(0)/G(1) phase cell cycle arrest induced by midazolam. Our data demonstrates that midazolam represses proliferation of human malignant glioma cells through inhibiting TRPM7 currents, which may be further potentiated by suppressing the expression of TRPM7. Our result indicates midazolam as a pharmacologic lead compound with brain-blood barrier permeability for targeting TRPM7 in the glioma. Twit Text FOAVip TRPM7 channel inhibition mediates midazolam-induced proliferation loss in human malignant glioma ????Tumour Biol http://www.kidney.de/pget.php?&tw=1&pmid=27629139 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27629139 #FOAvip English Wikipedia <ref>{{Cite pmid|27629139}}</ref> TRPM7 channel inhibition mediates midazolam-induced proliferation loss in human malignant glioma #MMPMID27629139 Chen J; Dou Y; Zheng X; Leng T; Lu X; Ouyang Y; Sun H; Xing F; Mai J; Gu J; Lu B; Yan G; Lin J; Zhu W Tumour Biol 2016[Nov]; 37 (11): 14721-14731 PMID27629139show ga The melastatin-like transient receptor potential 7 (TRPM7) has been implicated in proliferation or apoptosis of some cancers, indicating the potential of TRPM7 as an anti-anaplastic target. Here, we identified the characteristic TRPM7 channel currents in human malignant glioma MGR2 cells, which could be blocked by a pharmacologic inhibitor Gd(3+). We mined the clinical sample data from Oncomine Database and found that human malignant glioma tissues expressed higher TRPM7 mRNA than normal brain ones. Importantly, we identified a widely used clinical anesthetic midazolam as a TRPM7 inhibitor. Midazolam treatment for seconds suppressed the TRPM7 currents and calcium influx, and treatment for 48 h inhibited the TRPM7 expression. The inhibitory effect on TRPM7 accounts for the proliferation loss and G(0)/G(1) phase cell cycle arrest induced by midazolam. Our data demonstrates that midazolam represses proliferation of human malignant glioma cells through inhibiting TRPM7 currents, which may be further potentiated by suppressing the expression of TRPM7. Our result indicates midazolam as a pharmacologic lead compound with brain-blood barrier permeability for targeting TRPM7 in the glioma. |Anti-Anxiety Agents/*pharmacology[MESH] |Apoptosis/drug effects[MESH] |Blotting, Western[MESH] |Calcium/*metabolism[MESH] |Cell Cycle/drug effects[MESH] |Cell Proliferation/*drug effects[MESH] |Data Mining[MESH] |Databases, Factual[MESH] |Fluorescent Antibody Technique[MESH] |Glioma/*drug therapy/metabolism/pathology[MESH] |Humans[MESH] |Image Processing, Computer-Assisted/methods[MESH] |Midazolam/*pharmacology[MESH] |Protein Serine-Threonine Kinases/*antagonists & inhibitors/genetics/metabolism[MESH] |RNA, Messenger/genetics[MESH] |RNA, Small Interfering/genetics[MESH] |Real-Time Polymerase Chain Reaction[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |TRPM Cation Channels/*antagonists & inhibitors/genetics/metabolism[MESH]TRPM7 channel inhibition mediates midazolam-induced proliferation loss(epmc).pdf DeepDyve Pubget Overpricing