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10.1016/j.bbi.2016.08.019 http://scihub22266oqcxt.onion/10.1016/j.bbi.2016.08.019 27592314!5154920!27592314     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27592314.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Brain+Behav+Immun 2017 ; 59 (ä): 147-157 Nephropedia Template TP {{tp|p=27592314|t=2017. The protective effects of resveratrol on social stress-induced cytokine release and depressive-like behavior |pdf=|usr=}}{{27592314}} gab.com Text The protective effects of resveratrol on social stress-induced cytokine release and depressive-like behavior JO: Brain Behav Immun http://www.kidney.de/pget.php?&tw=1&pmid=27592314 #FOAvip Social stress is a risk factor for psychiatric disorders, however only a subset of the population is susceptible while others remain resilient. Inflammation has been linked to the pathogenesis of psychosocial disorders in humans and may underlie these individual differences. Using a resident-intruder paradigm capable of revealing individual differences in coping behavior and inflammatory responses, the present study determined if resveratrol (RSV; 0, 10, 30mg/kg/day) protected against persistent stress-induced inflammation in socially defeated rats. Furthermore, the antidepressant efficacy of RSV was evaluated using the sucrose preference test. Active coping rats were characterized by more time spent in upright postures and increased defeat latencies versus passive coping rats. Five days after defeat, flow cytometry revealed enhanced stimulation of proinflammatory proteins (IL-beta, TNF-alpha) in spleen cells of passive rats as compared to active coping and controls, an effect that was blocked by both doses of RSV. Furthermore, only passive coping rats exhibited increased proinflammatory proteins (IL-1beta, TNF-alpha, GM-CSF) in the locus coeruleus (LC), a noradrenergic brain region implicated in depression. Notably, only 30mg/kg RSV blocked LC neuroinflammation and importantly, was the only dose that blocked anhedonia. Alternatively, while stress had minimal impact on resting cytokines in the dorsal raphe (DR), RSV dose-dependently reduced DR cytokine expression. However, this did not result in changes in indoleamine 2,3-dioxygenase activity or serotonin levels. Taken together, these data suggest that social stress-induced depressive-like behavior evident in passive coping rats may be driven by stress-induced neuroinflammation and highlight natural anti-inflammatory agents to protect against social stress-related consequences. Twit Text FOAVip The protective effects of resveratrol on social stress-induced cytokine release and depressive-like behavior ????Brain Behav Immun http://www.kidney.de/pget.php?&tw=1&pmid=27592314 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27592314 #FOAvip English Wikipedia <ref>{{Cite pmid|27592314}}</ref> The protective effects of resveratrol on social stress-induced cytokine release and depressive-like behavior #MMPMID27592314 Finnell JE; Lombard CM; Melson MN; Singh NP; Nagarkatti M; Nagarkatti P; Fadel JR; Wood CS; Wood SK Brain Behav Immun 2017[Jan]; 59 (ä): 147-157 PMID27592314show ga Social stress is a risk factor for psychiatric disorders, however only a subset of the population is susceptible while others remain resilient. Inflammation has been linked to the pathogenesis of psychosocial disorders in humans and may underlie these individual differences. Using a resident-intruder paradigm capable of revealing individual differences in coping behavior and inflammatory responses, the present study determined if resveratrol (RSV; 0, 10, 30mg/kg/day) protected against persistent stress-induced inflammation in socially defeated rats. Furthermore, the antidepressant efficacy of RSV was evaluated using the sucrose preference test. Active coping rats were characterized by more time spent in upright postures and increased defeat latencies versus passive coping rats. Five days after defeat, flow cytometry revealed enhanced stimulation of proinflammatory proteins (IL-beta, TNF-alpha) in spleen cells of passive rats as compared to active coping and controls, an effect that was blocked by both doses of RSV. Furthermore, only passive coping rats exhibited increased proinflammatory proteins (IL-1beta, TNF-alpha, GM-CSF) in the locus coeruleus (LC), a noradrenergic brain region implicated in depression. Notably, only 30mg/kg RSV blocked LC neuroinflammation and importantly, was the only dose that blocked anhedonia. Alternatively, while stress had minimal impact on resting cytokines in the dorsal raphe (DR), RSV dose-dependently reduced DR cytokine expression. However, this did not result in changes in indoleamine 2,3-dioxygenase activity or serotonin levels. Taken together, these data suggest that social stress-induced depressive-like behavior evident in passive coping rats may be driven by stress-induced neuroinflammation and highlight natural anti-inflammatory agents to protect against social stress-related consequences. |*Social Environment[MESH] |Adaptation, Psychological[MESH] |Anhedonia[MESH] |Animals[MESH] |Antioxidants/*therapeutic use[MESH] |Cytokines/*metabolism[MESH] |Depressive Disorder/*drug therapy/metabolism/*psychology[MESH] |Dose-Response Relationship, Drug[MESH] |Locus Coeruleus/metabolism[MESH] |Male[MESH] |Raphe Nuclei/metabolism[MESH] |Rats[MESH] |Rats, Long-Evans[MESH] |Rats, Sprague-Dawley[MESH] |Resveratrol[MESH] |Spleen/metabolism[MESH] |Stilbenes/*therapeutic use[MESH]The protective effects of resveratrol on social stress-induced cytokin(epmc).pdf DeepDyve Pubget Overpricing