Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1183/13993003.01826-2015 http://scihub22266oqcxt.onion/10.1183/13993003.01826-2015 27587556!?!27587556 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27587556&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Eur+Respir+J 2016 ; 48 (4): 1171-1183 Nephropedia Template TP {{tp|p=27587556|t=2016. Peripheral blood myeloid-derived suppressor cells reflect disease status in idiopathic pulmonary fibrosis |pdf=|usr=}}{{27587556}} gab.com Text Peripheral blood myeloid-derived suppressor cells reflect disease status in idiopathic pulmonary fibrosis JO: Eur Respir J http://www.kidney.de/pget.php?&tw=1&pmid=27587556 #FOAvip Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative disease with irreversible lung function loss and poor survival. Myeloid-derived suppressor cells (MDSC) are associated with poor prognosis in cancer, facilitating immune evasion. The abundance and function of MDSC in IPF is currently unknown.Fluorescence-activated cell sorting was performed in 170 patients (IPF: n=69; non-IPF interstitial lung disease (ILD): n=56; chronic obstructive pulmonary disease (COPD): n=23; healthy controls: n=22) to quantify blood MDSC and lymphocyte subtypes. MDSC abundance was correlated with lung function, MDSC localisation was performed by immunofluorescence. Peripheral blood mononuclear cell (PBMC) mRNA levels were analysed by qRT-PCR.We detected increased MDSC in IPF and non-IPF ILD compared with controls (30.99+/-15.61% versus 18.96+/-8.17%, p</=0.01). Circulating MDSC inversely correlated with maximum vital capacity (r= -0.48, p</=0.0001) in IPF, but not in COPD or non-IPF ILD. MDSC suppressed autologous T-cells. The mRNA levels of co-stimulatory T-cell signals were significantly downregulated in IPF PBMC. Importantly, CD33(+)CD11b(+) cells, suggestive of MDSC, were detected in fibrotic niches of IPF lungs.We identified increased MDSC in IPF and non-IPF ILD, suggesting that elevated MDSC may cause a blunted immune response. MDSC inversely correlate with lung function only in IPF, identifying them as potent biomarkers for disease progression. Controlling expansion and accumulation of MDSC, or blocking their T-cell suppression, represents a promising therapy in IPF. Twit Text FOAVip Peripheral blood myeloid-derived suppressor cells reflect disease status in idiopathic pulmonary fibrosis ????Eur Respir J http://www.kidney.de/pget.php?&tw=1&pmid=27587556 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27587556 #FOAvip English Wikipedia <ref>{{Cite pmid|27587556}}</ref> Peripheral blood myeloid-derived suppressor cells reflect disease status in idiopathic pulmonary fibrosis #MMPMID27587556 Fernandez IE; Greiffo FR; Frankenberger M; Bandres J; Heinzelmann K; Neurohr C; Hatz R; Hartl D; Behr J; Eickelberg O Eur Respir J 2016[Oct]; 48 (4): 1171-1183 PMID27587556show ga Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative disease with irreversible lung function loss and poor survival. Myeloid-derived suppressor cells (MDSC) are associated with poor prognosis in cancer, facilitating immune evasion. The abundance and function of MDSC in IPF is currently unknown.Fluorescence-activated cell sorting was performed in 170 patients (IPF: n=69; non-IPF interstitial lung disease (ILD): n=56; chronic obstructive pulmonary disease (COPD): n=23; healthy controls: n=22) to quantify blood MDSC and lymphocyte subtypes. MDSC abundance was correlated with lung function, MDSC localisation was performed by immunofluorescence. Peripheral blood mononuclear cell (PBMC) mRNA levels were analysed by qRT-PCR.We detected increased MDSC in IPF and non-IPF ILD compared with controls (30.99+/-15.61% versus 18.96+/-8.17%, p |Aged[MESH] |Biomarkers/blood[MESH] |Case-Control Studies[MESH] |Cell Separation[MESH] |Coculture Techniques[MESH] |Disease Progression[MESH] |Female[MESH] |Flow Cytometry[MESH] |Humans[MESH] |Idiopathic Pulmonary Fibrosis/*immunology/physiopathology[MESH] |Immune System[MESH] |Leukocytes, Mononuclear/*immunology[MESH] |Lung Diseases, Interstitial/blood[MESH] |Lung/pathology[MESH] |Male[MESH] |Middle Aged[MESH] |Myeloid-Derived Suppressor Cells/*cytology[MESH] |Prognosis[MESH] |Prospective Studies[MESH] |Pulmonary Disease, Chronic Obstructive/blood[MESH]Peripheral blood myeloid-derived suppressor cells reflect disease stat(epmc).pdf DeepDyve Pubget Overpricing