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10.1016/j.ajpath.2016.06.020 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2016.06.020 27565038/?report=reader!5222985!27565038     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Pathol 2016 ; 186 (10): 2650-64 Nephropedia Template TP {{tp|p=27565038|t=2016. Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90 |pdf=|usr=}}{{27565038}} gab.com Text Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90 JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27565038 #FOAvip Tissue injury triggers the activation and differentiation of multiple cell types to minimize damage and initiate repair processes. In systemic sclerosis, these repair processes appear to run unchecked, leading to aberrant remodeling and fibrosis of the skin and multiple internal organs, yet the fundamental pathological defect remains unknown. We describe herein a transition wherein the abundant CD34(+) dermal fibroblasts present in healthy human skin disappear in the skin of systemic sclerosis patients, and CD34(-), podoplanin(+), and CD90(+) fibroblasts appear. This transition is limited to the upper dermis in several inflammatory skin diseases, yet in systemic sclerosis, it can occur in all regions of the dermis. In vitro, primary dermal fibroblasts readily express podoplanin in response to the inflammatory stimuli tumor necrosis factor and IL-1beta. Furthermore, we show that on acute skin injury in both human and murine settings, this transition occurs quickly, consistent with a response to inflammatory signaling. Transitioned fibroblasts partially resemble the cells that form the reticular networks in organized lymphoid tissues, potentially linking two areas of fibroblast research. These results allow for the visualization and quantification of a basic stage of fibroblast differentiation in inflammatory and fibrotic diseases in the skin. Twit Text FOAVip Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90 ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27565038 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27565038 #FOAvip English Wikipedia <ref>{{Cite pmid|27565038}}</ref> Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90 #MMPMID27565038 Nazari B; Rice LM; Stifano G; Barron AM; Wang YM; Korndorf T; Lee J; Bhawan J; Lafyatis R; Browning JL Am J Pathol 2016[Oct]; 186 (10): 2650-64 PMID27565038show ga Tissue injury triggers the activation and differentiation of multiple cell types to minimize damage and initiate repair processes. In systemic sclerosis, these repair processes appear to run unchecked, leading to aberrant remodeling and fibrosis of the skin and multiple internal organs, yet the fundamental pathological defect remains unknown. We describe herein a transition wherein the abundant CD34(+) dermal fibroblasts present in healthy human skin disappear in the skin of systemic sclerosis patients, and CD34(-), podoplanin(+), and CD90(+) fibroblasts appear. This transition is limited to the upper dermis in several inflammatory skin diseases, yet in systemic sclerosis, it can occur in all regions of the dermis. In vitro, primary dermal fibroblasts readily express podoplanin in response to the inflammatory stimuli tumor necrosis factor and IL-1beta. Furthermore, we show that on acute skin injury in both human and murine settings, this transition occurs quickly, consistent with a response to inflammatory signaling. Transitioned fibroblasts partially resemble the cells that form the reticular networks in organized lymphoid tissues, potentially linking two areas of fibroblast research. These results allow for the visualization and quantification of a basic stage of fibroblast differentiation in inflammatory and fibrotic diseases in the skin. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Animals[MESH] |Cell Differentiation[MESH] |Dermis/immunology/pathology[MESH] |Female[MESH] |Fibroblasts/immunology/pathology[MESH] |Fibrosis/immunology/*pathology[MESH] |Humans[MESH] |Interleukin-1beta/immunology/metabolism[MESH] |Male[MESH] |Membrane Glycoproteins/*metabolism[MESH] |Mice[MESH] |Middle Aged[MESH] |Scleroderma, Systemic/immunology/*pathology[MESH] |Skin/immunology/pathology[MESH] |Thy-1 Antigens/*metabolism[MESH]Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin an(epmc).pdf DeepDyve Pubget Overpricing