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suck abstract from ncbi


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pmid2755214      Magnesium 1989 ; 8 (2): 71-6
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  • Comparison of potassium alone and potassium-magnesium supplementation in patients with heart failure using hydrochlorothiazide #MMPMID2755214
  • Kohvakka A; Luurila O; Gordin A; Sundberg S
  • Magnesium 1989[]; 8 (2): 71-6 PMID2755214show ga
  • Supplementation of potassium alone and in combination with magnesium was compared in 10 patients with chronic compensated heart failure receiving hydrochlorothiazide 50 mg twice daily for the whole trial. After a 3-week run-in period, the patients were randomized to receive active supplementation for 6 weeks in a double-blind cross-over manner. A 3-week wash-out period was kept in between. Addition of 2 g potassium chloride daily (27 mmol K+) did not efficiently correct the serum potassium concentration. After the combined supplementation of 2 g potassium and 1 g magnesium (27 mmol K+ and 17 mmol Mg2+ daily), both serum potassium and magnesium concentrations increased statistically significantly during the first 2 weeks of treatment. After a longer treatment of 6 weeks, the effect of combined supplementation was less clear, even though a trend toward a better maintenance of serum potassium was still evident.
  • |Aged[MESH]
  • |Blood Pressure/drug effects[MESH]
  • |Body Weight/drug effects[MESH]
  • |Double-Blind Method[MESH]
  • |Female[MESH]
  • |Heart Failure/*drug therapy[MESH]
  • |Heart Rate/drug effects[MESH]
  • |Humans[MESH]
  • |Hydrochlorothiazide/*adverse effects/therapeutic use[MESH]
  • |Magnesium Deficiency/chemically induced/*prevention & control[MESH]
  • |Magnesium/*administration & dosage/metabolism[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Potassium Deficiency/chemically induced/*prevention & control[MESH]
  • |Potassium/*administration & dosage/metabolism[MESH]


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