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10.1080/19336950.2016.1207022 http://scihub22266oqcxt.onion/10.1080/19336950.2016.1207022 27540685!5279881!27540685     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Channels+(Austin) 2017 ; 11 (1): 46-54 Nephropedia Template TP {{tp|p=27540685|t=2017. Styrax blocks inward and outward current of Kir2 1 channel |pdf=|usr=}}{{27540685}} gab.com Text Styrax blocks inward and outward current of Kir2 1 channel JO: Channels (Austin) http://www.kidney.de/pget.php?&tw=1&pmid=27540685 #FOAvip Kir2.1 plays key roles in setting rest membrane potential and modulation of cell excitability. Mutations of Kir2.1, such as D172N or E299V, inducing gain-of-function, can cause type3 short QT syndrome (SQT3) due to the enlarged outward currents. So far, there is no clinical drug target to block the currents of Kir2.1. Here, we identified a novel blocker of Kir2.1, styrax, which is a kind of natural compound selected from traditional Chinese medicine. Our data show that styrax can abolish the inward and outward currents of Kir2.1. The IC(50) of styrax for WT, D172N and E299V are 0.0113 +/- 0.00075, 0.0204 +/- 0.0048 and 0.0122 +/- 0.0012 (in volume), respectively. The results indicate that styrax can serve as a novel blocker for Kir2.1. Twit Text FOAVip Styrax blocks inward and outward current of Kir2 1 channel ????Channels (Austin) http://www.kidney.de/pget.php?&tw=1&pmid=27540685 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27540685 #FOAvip English Wikipedia <ref>{{Cite pmid|27540685}}</ref> Styrax blocks inward and outward current of Kir2 1 channel #MMPMID27540685 Ren S; Pang C; Li J; Huang Y; Zhang S; Zhan Y; An H Channels (Austin) 2017[Jan]; 11 (1): 46-54 PMID27540685show ga Kir2.1 plays key roles in setting rest membrane potential and modulation of cell excitability. Mutations of Kir2.1, such as D172N or E299V, inducing gain-of-function, can cause type3 short QT syndrome (SQT3) due to the enlarged outward currents. So far, there is no clinical drug target to block the currents of Kir2.1. Here, we identified a novel blocker of Kir2.1, styrax, which is a kind of natural compound selected from traditional Chinese medicine. Our data show that styrax can abolish the inward and outward currents of Kir2.1. The IC(50) of styrax for WT, D172N and E299V are 0.0113 +/- 0.00075, 0.0204 +/- 0.0048 and 0.0122 +/- 0.0012 (in volume), respectively. The results indicate that styrax can serve as a novel blocker for Kir2.1. |*Styrax[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Medicine, Chinese Traditional[MESH] |Plant Preparations/*pharmacology[MESH] |Potassium Channel Blockers/*pharmacology[MESH]Styrax blocks inward and outward current of Kir2 1 channel (epmc).pdf DeepDyve Pubget Overpricing