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10.7554/eLife.17200 http://scihub22266oqcxt.onion/10.7554/eLife.17200 27536874!5008907!27536874     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27536874&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Elife 2016 ; 5 (?): ? Nephropedia Template TP {{tp|p=27536874|t=2016. The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development |pdf=|usr=}}{{27536874}} gab.com Text The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=27536874 #FOAvip Wingless (Wg)/Wnt signaling is conserved in all metazoan animals and plays critical roles in development. The Wg/Wnt morphogen reception is essential for signal activation, whose activity is mediated through the receptor complex and a scaffold protein Dishevelled (Dsh). We report here that the exon junction complex (EJC) activity is indispensable for Wg signaling by maintaining an appropriate level of Dsh protein for Wg ligand reception in Drosophila. Transcriptome analyses in Drosophila wing imaginal discs indicate that the EJC controls the splicing of the cell polarity gene discs large 1 (dlg1), whose coding protein directly interacts with Dsh. Genetic and biochemical experiments demonstrate that Dlg1 protein acts independently from its role in cell polarity to protect Dsh protein from lysosomal degradation. More importantly, human orthologous Dlg protein is sufficient to promote Dvl protein stabilization and Wnt signaling activity, thus revealing a conserved regulatory mechanism of Wg/Wnt signaling by Dlg and EJC. Twit Text FOAVip The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=27536874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27536874 #FOAvip English Wikipedia <ref>{{Cite pmid|27536874}}</ref> The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development #MMPMID27536874 Liu M; Li Y; Liu A; Li R; Su Y; Du J; Li C; Zhu AJ Elife 2016[Aug]; 5 (?): ? PMID27536874show ga Wingless (Wg)/Wnt signaling is conserved in all metazoan animals and plays critical roles in development. The Wg/Wnt morphogen reception is essential for signal activation, whose activity is mediated through the receptor complex and a scaffold protein Dishevelled (Dsh). We report here that the exon junction complex (EJC) activity is indispensable for Wg signaling by maintaining an appropriate level of Dsh protein for Wg ligand reception in Drosophila. Transcriptome analyses in Drosophila wing imaginal discs indicate that the EJC controls the splicing of the cell polarity gene discs large 1 (dlg1), whose coding protein directly interacts with Dsh. Genetic and biochemical experiments demonstrate that Dlg1 protein acts independently from its role in cell polarity to protect Dsh protein from lysosomal degradation. More importantly, human orthologous Dlg protein is sufficient to promote Dvl protein stabilization and Wnt signaling activity, thus revealing a conserved regulatory mechanism of Wg/Wnt signaling by Dlg and EJC. |*RNA Splicing[MESH] |*Wnt Signaling Pathway[MESH] |Adaptor Proteins, Signal Transducing[MESH] |Animals[MESH] |Discs Large Homolog 1 Protein[MESH] |Dishevelled Proteins/*metabolism[MESH] |Drosophila Proteins/*biosynthesis/*genetics/*metabolism[MESH] |Drosophila/*embryology[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Membrane Proteins[MESH] |Tumor Suppressor Proteins/*biosynthesis/*genetics[MESH]The exon junction complex regulates the splicing of cell polarity gene(epmc).pdf DeepDyve Pubget Overpricing